| Tag | Content |
|---|
| CPLM ID | CPLM-027467 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Ribonucleoside-diphosphate reductase |
Protein Synonyms/Alias | |
Gene Name | PF14_0352 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Plasmodium falciparum (isolate 3D7) |
NCBI Taxa ID | 36329 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 790 | QAATDAIKFTVDTHV | acetylation | [1] |
|
Reference | [1] Extensive lysine acetylation occurs in evolutionarily conserved metabolic pathways and parasite-specific functions during Plasmodium falciparum intraerythrocytic development. Miao J, Lawrence M, Jeffers V, Zhao F, Parker D, Ge Y, Sullivan WJ Jr, Cui L. Mol Microbiol. 2013 Aug;89(4):660-75. [ PMID: 23796209] |
Functional Description | Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity). |
Sequence Annotation | |
Keyword | Complete proteome; DNA replication; Oxidoreductase; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 847 AA |
Protein Sequence | MGDNVKRLPL PSENGEIKKS TSGRLSDDGI KRTPSGKPIQ TMYVLNRKGE EEDISFDQIL 60
KRIQRLSYGL HELVDPARVT QGVINGMYSG IKTCELDELA AQTCAYMATT HPDFSILAAR 120
ITTDNLHKNT SDDVAEVAEA LYTYKDVRGR PASLISKEVY DFILLHKDRL NKEIDYTRDF 180
NYDYFGFKTL ERSYLLRINN KIIERPQHLL MRVSIGIHID DIDKALETYH LMSQKYFTHA 240
TPTLFNSGTP RPQMSSCFLL SMKADSIEGI FETLKQCALI SKTAGGIGVA VQDIRGQNSY 300
IRGTNGISNG LVPMLRVFND TARYVDQGGG KRKGSFAVYI EPWHSDIFEF LDLRKNHGKE 360
ELRARDLFYA VWVPDLFMKR VKENKNWTLM CPNECPGLSE TWGEEFEKLY TKYEEENMGK 420
KTVLAQDLWF AILQSQIETG VPYMLYKDSC NAKSNQKNLG TIKCSNLCCE IIEYTSPDEV 480
AVCNLASIAL CKFVDLEKKE FNFKKLYEIT KIITRNLDKI IERNYYPVKE AKTSNTRHRP 540
IGIGVQGLAD TFMLLRYPYE SDAAKELNKR IFETMYYAAL EMSVELASIH GPYESYQGSP 600
ASQGILQFDM WNAKVDNKYW DWDELKAKIR KHGLRNSLLL APMPTASTSQ ILGNNESFEP 660
YTSNIYYRRV LSGEFFVVNP HLLKDLFDRG LWDEDMKQQL IAHNGSIQYI SEIPDDLKEL 720
YKTVWEIKQK NIIDMAADRG IFIDQSQSLN IYIQKPTFAK LSSMHFYGWE KGLKTGAYYL 780
RTQAATDAIK FTVDTHVAKN AVKLKNADGV QITREVSRET ISTESTVTQN VCPLRRNNDE 840
QCLMCSG 847 |
Gene Ontology | GO:0005971; C:ribonucleoside-diphosphate reductase complex; IEA:InterPro. GO:0005524; F:ATP binding; IEA:InterPro. GO:0004748; F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor; IEA:EC. GO:0006260; P:DNA replication; IEA:UniProtKB-UniPathway. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |