UniProt Accession

 NCPP_ECOLI; P39411; Q2M5S3 

Genbank Protein ID

 U14003; U00096; AP009048; J01715; L13768 

Genbank Nucleotide ID

 AAA97290.1; AAC77347.2; BAE78383.1; AAA72135.1 

Protein Name

 Non-canonical purine NTP phosphatase 

Protein Synonyms/Alias

 Inosine triphosphatase; ITPase; Non-standard purine NTP phosphatase; Nucleoside-triphosphate phosphatase; NTPase; Xanthosine triphosphatase; XTPase 

Gene Name

 yjjX 

Gene Synonyms/Alias

 b4394; JW5801 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
113	LPAVILEKVREGEAL	acetylation	[1]
136	GIDEIGRKEGAIGVF	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions. ITP is the best substrate, followed by XTP, GDP or dITP. Also implicated in the resistance against the thiamine metabolism inhibitors bacimethrin and CF3-HMP. 

Sequence Annotation

 REGION 8 13 Substrate binding.
 REGION 68 69 Substrate binding (By similarity).
 METAL 38 38 Manganese or magnesium (By similarity).
 METAL 68 68 Manganese or magnesium (By similarity).  

Keyword

 3D-structure; Antibiotic resistance; Complete proteome; Hydrolase; Magnesium; Manganese; Metal-binding; Nucleotide metabolism; Nucleotide-binding; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 170 AA 

Protein Sequence

Gene Ontology

 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0017111; F:nucleoside-triphosphatase activity; IDA:EcoCyc.
 GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
 GO:0009117; P:nucleotide metabolic process; IEA:UniProtKB-KW.
 GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
 GO:0006772; P:thiamine metabolic process; EXP:EcoliWiki. 

Interpro

 IPR002786; Non_canon_purine_NTPase.
 IPR026533; NTPase/PRRC1. 

Pfam

 PF01931; NTPase_I-T 

SMART

  

PROSITE

  

PRINTS