CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-011997
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Zinc finger and BTB domain-containing protein 17 
Protein Synonyms/Alias
 Myc-interacting zinc finger protein 1; Miz-1; Zinc finger protein 151; Zinc finger protein 60 
Gene Name
 ZBTB17 
Gene Synonyms/Alias
 MIZ1; ZNF151; ZNF60 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
135LATEGGDKRAKEEKVubiquitination[1]
332IRIHTGEKPFSCRECubiquitination[1]
341FSCRECSKAFSDPAAubiquitination[1]
350FSDPAACKAHEKTHSubiquitination[1]
433SFSDPTSKMRHLETHacetylation[2]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 
Functional Description
 Plays a critical role in early lymphocyte development, where it is essential to prevent apoptosis in lymphoid precursors, allowing them to survive in response to IL7 and undergo proper lineage commitment (By similarity). Transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. Has been shown to bind to the promoters of adenovirus major late protein and cyclin D1 and activate transcription. Required for early embryonic development during gastrulation. 
Sequence Annotation
 DOMAIN 1 104 BTB.
 ZN_FING 306 328 C2H2-type 1.
 ZN_FING 334 356 C2H2-type 2.
 ZN_FING 362 384 C2H2-type 3.
 ZN_FING 390 412 C2H2-type 4.
 ZN_FING 418 440 C2H2-type 5.
 ZN_FING 446 468 C2H2-type 6.
 ZN_FING 474 496 C2H2-type 7.
 ZN_FING 502 524 C2H2-type 8.
 ZN_FING 530 552 C2H2-type 9.
 ZN_FING 558 580 C2H2-type 10.
 ZN_FING 586 608 C2H2-type 11.
 ZN_FING 614 637 C2H2-type 12.
 ZN_FING 717 739 C2H2-type 13.
 REGION 269 308 Interaction with MYC.
 REGION 637 803 Interaction with HCFC1.
 REGION 637 718 Interaction with MYC.
 CROSSLNK 397 397 Glycyl lysine isopeptide (Lys-Gly)
 CROSSLNK 481 481 Glycyl lysine isopeptide (Lys-Gly)  
Keyword
 3D-structure; Alternative splicing; Complete proteome; Developmental protein; DNA-binding; Isopeptide bond; Metal-binding; Nucleus; Reference proteome; Repeat; Transcription; Transcription regulation; Ubl conjugation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 803 AA 
Protein Sequence
MDFPQHSQHV LEQLNQQRQL GLLCDCTFVV DGVHFKAHKA VLAACSEYFK MLFVDQKDVV 60
HLDISNAAGL GQVLEFMYTA KLSLSPENVD DVLAVATFLQ MQDIITACHA LKSLAEPATS 120
PGGNAEALAT EGGDKRAKEE KVATSTLSRL EQAGRSTPIG PSRDLKEERG GQAQSAASGA 180
EQTEKADAPR EPPPVELKPD PTSGMAAAEA EAALSESSEQ EMEVEPARKG EEEQKEQEEQ 240
EEEGAGPAEV KEEGSQLENG EAPEENENEE SAGTDSGQEL GSEARGLRSG TYGDRTESKA 300
YGSVIHKCED CGKEFTHTGN FKRHIRIHTG EKPFSCRECS KAFSDPAACK AHEKTHSPLK 360
PYGCEECGKS YRLISLLNLH KKRHSGEARY RCEDCGKLFT TSGNLKRHQL VHSGEKPYQC 420
DYCGRSFSDP TSKMRHLETH DTDKEHKCPH CDKKFNQVGN LKAHLKIHIA DGPLKCRECG 480
KQFTTSGNLK RHLRIHSGEK PYVCIHCQRQ FADPGALQRH VRIHTGEKPC QCVMCGKAFT 540
QASSLIAHVR QHTGEKPYVC ERCGKRFVQS SQLANHIRHH DNIRPHKCSV CSKAFVNVGD 600
LSKHIIIHTG EKPYLCDKCG RGFNRVDNLR SHVKTVHQGK AGIKILEPEE GSEVSVVTVD 660
DMVTLATEAL AATAVTQLTV VPVGAAVTAD ETEVLKAEIS KAVKQVQEED PNTHILYACD 720
SCGDKFLDAN SLAQHVRIHT AQALVMFQTD ADFYQQYGPG GTWPAGQVLQ AGELVFRPRD 780
GAEGQPALAE TSPTAPECPP PAE 803 
Gene Ontology
 GO:0005654; C:nucleoplasm; TAS:Reactome.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IDA:UniProtKB.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006987; P:activation of signaling protein activity involved in unfolded protein response; TAS:Reactome.
 GO:0044267; P:cellular protein metabolic process; TAS:Reactome.
 GO:0007398; P:ectoderm development; IEA:Compara.
 GO:0001702; P:gastrulation with mouth forming second; IEA:Compara.
 GO:0045786; P:negative regulation of cell cycle; TAS:UniProtKB.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; IEA:Compara.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR000210; BTB/POZ-like.
 IPR011333; BTB/POZ_fold.
 IPR013069; BTB_POZ.
 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR013087; Znf_C2H2/integrase_DNA-bd. 
Pfam
 PF00651; BTB 
SMART
 SM00225; BTB
 SM00355; ZnF_C2H2 
PROSITE
 PS50097; BTB
 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 
PRINTS