UniProt Accession

 ANKH_HUMAN; Q9HCJ1; B2RCA7; D3DTD4; Q9NQW2 

Genbank Protein ID

 AF274753; AB046801; AY358503; AK315012; CH471102; CH471102; BC009835; BC014526 

Genbank Nucleotide ID

 AAF88039.1; BAB13407.1; AAQ88867.1; BAG37504.1; EAX08034.1; EAX08035.1; AAH09835.1; AAH14526.1 

Protein Name

 Progressive ankylosis protein homolog 

Protein Synonyms/Alias

 ANK 

Gene Name

 ANKH 

Gene Synonyms/Alias

 KIAA1581; UNQ241/PRO274 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
70	TGPMSDFKNVGLVFV	ubiquitination	[1]
80	GLVFVNSKRDRTKAV	ubiquitination	[1]
127	VDESVGSKTRRAFLY	ubiquitination	[1, 2]
305	AVYPAFDKNNPSNKL	ubiquitination	[3]

Reference

 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Regulates intra- and extracellular levels of inorganic pyrophosphate (PPi), probably functioning as PPi transporter. 

Sequence Annotation

  

Keyword

 Complete proteome; Deafness; Disease mutation; Membrane; Phosphate transport; Reference proteome; Transmembrane; Transmembrane helix; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 492 AA 

Protein Sequence

Gene Ontology

 GO:0005887; C:integral to plasma membrane; ISS:UniProtKB.
 GO:0019867; C:outer membrane; TAS:UniProtKB.
 GO:0030504; F:inorganic diphosphate transmembrane transporter activity; IDA:UniProtKB.
 GO:0005315; F:inorganic phosphate transmembrane transporter activity; IDA:UniProtKB.
 GO:0015114; F:phosphate ion transmembrane transporter activity; IEA:InterPro.
 GO:0007626; P:locomotory behavior; NAS:UniProtKB.
 GO:0030500; P:regulation of bone mineralization; ISS:UniProtKB.
 GO:0001501; P:skeletal system development; NAS:UniProtKB. 

Interpro

 IPR009887; ANKH. 

Pfam

 PF07260; ANKH 

SMART

  

PROSITE

  

PRINTS