UniProt Accession

 B7ZC18_MOUSE; B7ZC18 

Genbank Protein ID

 AL591466 

Genbank Nucleotide ID

  

Protein Name

 Signal transducer and activator of transcription 3 

Protein Synonyms/Alias

  

Gene Name

 Stat3 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
151	DDFDFNYKTLKSQGD	ubiquitination	[1]
154	DFNYKTLKSQGDMQD	ubiquitination	[1]
218	DEELADWKRRQQIAC	ubiquitination	[1]
268	LQQKVSYKGDPIVQH	ubiquitination	[1]
292	ELFRNLMKSAFVVER	ubiquitination	[1]
337	PELNYQLKIKVCIDK	ubiquitination	[1]
344	KIKVCIDKDSGDVAA	acetylation	[2]
600	VTFTWVEKDISGKTQ	ubiquitination	[1]
605	VEKDISGKTQIQSVE	acetylation	[3, 4]
605	VEKDISGKTQIQSVE	ubiquitination	[1]
681	GSAAPYLKTKFICVT	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [4] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 744 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:MGI.
 GO:0005634; C:nucleus; IDA:MGI.
 GO:0005886; C:plasma membrane; IDA:MGI.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0043565; F:sequence-specific DNA binding; IDA:MGI.
 GO:0000981; F:sequence-specific DNA binding RNA polymerase II transcription factor activity; IDA:MGI.
 GO:0004871; F:signal transducer activity; IEA:InterPro.
 GO:0008283; P:cell proliferation; IDA:MGI.
 GO:0042755; P:eating behavior; IMP:MGI.
 GO:0001754; P:eye photoreceptor cell differentiation; IMP:MGI.
 GO:0042593; P:glucose homeostasis; IMP:MGI.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:MGI.
 GO:0040014; P:regulation of multicellular organism growth; IMP:MGI.
 GO:0019953; P:sexual reproduction; IMP:MGI.
 GO:0019827; P:stem cell maintenance; IMP:MGI.
 GO:0001659; P:temperature homeostasis; IMP:MGI. 

Interpro

 IPR011992; EF-hand-like_dom.
 IPR008967; p53-like_TF_DNA-bd.
 IPR000980; SH2.
 IPR013800; STAT_TF_alpha.
 IPR015988; STAT_TF_coiled-coil.
 IPR001217; STAT_TF_core.
 IPR013801; STAT_TF_DNA-bd.
 IPR012345; STAT_TF_DNA-bd_sub.
 IPR013799; STAT_TF_prot_interaction. 

Pfam

 PF00017; SH2
 PF01017; STAT_alpha
 PF02864; STAT_bind
 PF02865; STAT_int 

SMART

 SM00252; SH2
 SM00964; STAT_int 

PROSITE

 PS50001; SH2 

PRINTS