UniProt Accession

 RNT1_YEAST; Q02555; D6W065; Q04008; Q05038 

Genbank Protein ID

 U27016; Z48756; Z49939; BK006946 

Genbank Nucleotide ID

 AAB04172.1; CAA88649.1; CAA90210.1; DAA10139.1 

Protein Name

 Ribonuclease 3 

Protein Synonyms/Alias

 Ribonuclease III; RNase III 

Gene Name

 RNT1 

Gene Synonyms/Alias

 YMR239C; YM9408.01C; YM9959.21 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
456	PRSESVLKDPSQKNK	acetylation	[1]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 

Functional Description

 DsRNA-specific nuclease that cleaves eukaryotic pre- ribosomal RNA at the U3 snoRNP-dependent A0 site in the 5'- external transcribed spacer (ETS) and in the 3'-ETS. In vitro, cleaves synthetic 5'-ETS RNA A0 site in the absence of snoRNA or other factors. Has an essential growth function in addition to pre-rRNA processing. 

Sequence Annotation

 DOMAIN 227 331 RNase III.
 DOMAIN 369 437 DRBM.  

Keyword

 3D-structure; Complete proteome; Endonuclease; Hydrolase; Nuclease; Reference proteome; RNA-binding. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 471 AA 

Protein Sequence

Gene Ontology

 GO:0005730; C:nucleolus; IDA:SGD.
 GO:0005654; C:nucleoplasm; IDA:SGD.
 GO:0003725; F:double-stranded RNA binding; IEA:InterPro.
 GO:0004525; F:ribonuclease III activity; IDA:SGD.
 GO:0034963; P:box C/D snoRNA processing; IMP:SGD.
 GO:0034964; P:box H/ACA snoRNA processing; IMP:SGD.
 GO:0006325; P:chromatin organization; IMP:SGD.
 GO:0006379; P:mRNA cleavage; IDA:SGD.
 GO:0060237; P:regulation of fungal-type cell wall organization; IMP:SGD.
 GO:0016075; P:rRNA catabolic process; IEA:InterPro.
 GO:0006364; P:rRNA processing; IMP:SGD.
 GO:0009303; P:rRNA transcription; IMP:SGD.
 GO:0030847; P:termination of RNA polymerase II transcription, exosome-dependent; IDA:SGD.
 GO:0034473; P:U1 snRNA 3'-end processing; IMP:SGD.
 GO:0034475; P:U4 snRNA 3'-end processing; IMP:SGD.
 GO:0034476; P:U5 snRNA 3'-end processing; IMP:SGD. 

Interpro

 IPR001159; Ds-RNA-bd.
 IPR014720; dsRNA-bd-like_dom.
 IPR011907; RNase_III.
 IPR000999; RNase_III_dom. 

Pfam

 PF00035; dsrm
 PF00636; Ribonuclease_3 

SMART

 SM00358; DSRM
 SM00535; RIBOc 

PROSITE

 PS50137; DS_RBD
 PS00517; RNASE_3_1
 PS50142; RNASE_3_2 

PRINTS