CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015426
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Dehydrogenase/reductase SDR family member 13 
Protein Synonyms/Alias
  
Gene Name
 DHRS13 
Gene Synonyms/Alias
 UNQ419/PRO853 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
50GANSGIGKMTALELAmethylation[1]
50GANSGIGKMTALELAubiquitination[2]
201LRAYADTKLANVLFAubiquitination[2, 3, 4, 5, 6]
308HRLWEASKRLAGLGPubiquitination[2]
Reference
 [1] Large-scale global identification of protein lysine methylation in vivo.
 Cao XJ, Arnaudo AM, Garcia BA.
 Epigenetics. 2013 May 1;8(5):477-85. [PMID: 23644510]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [5] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [6] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789
Functional Description
 Putative oxidoreductase (Potential). 
Sequence Annotation
 NP_BIND 43 49 NAD or NADP (By similarity).
 ACT_SITE 197 197 Proton acceptor (By similarity).
 BINDING 170 170 Substrate (Potential).
 MOD_RES 356 356 Phosphoserine (By similarity).
 MOD_RES 360 360 Phosphoserine (By similarity).  
Keyword
 Alternative splicing; Complete proteome; NAD; NADP; Oxidoreductase; Phosphoprotein; Polymorphism; Reference proteome; Secreted; Signal. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 377 AA 
Protein Sequence
MEALLLGAGL LLGAYVLVYY NLVKAPPCGG MGNLRGRTAV VTGANSGIGK MTALELARRG 60
ARVVLACRSQ ERGEAAAFDL RQESGNNEVI FMALDLASLA SVRAFATAFL SSEPRLDILI 120
HNAGISSCGR TREAFNLLLR VNHIGPFLLT HLLLPCLKAC APSRVVVVAS AAHCRGRLDF 180
KRLDRPVVGW RQELRAYADT KLANVLFARE LANQLEATGV TCYAAHPGPV NSELFLRHVP 240
GWLRPLLRPL AWLVLRAPRG GAQTPLYCAL QEGIEPLSGR YFANCHVEEV PPAARDDRAA 300
HRLWEASKRL AGLGPGEDAE PDEDPQSEDS EAPSSLSTPH PEEPTVSQPY PSPQSSPDLS 360
KMTHRIQAKV EPEIQLS 377 
Gene Ontology
 GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
 GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW. 
Interpro
 IPR002198; DH_sc/Rdtase_SDR.
 IPR002347; Glc/ribitol_DH.
 IPR016040; NAD(P)-bd_dom. 
Pfam
 PF00106; adh_short 
SMART
  
PROSITE
 PS00061; ADH_SHORT 
PRINTS
 PR00081; GDHRDH.