| Tag | Content |
|---|
| CPLM ID | CPLM-020631 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Histone-lysine N-methyltransferase SMYD3 |
Protein Synonyms/Alias | SET and MYND domain-containing protein 3; Zinc finger MYND domain-containing protein 1 |
Gene Name | Smyd3 |
Gene Synonyms/Alias | Zmynd1 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 378 | VQVMKVGKLQLHQGM | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Histone methyltransferase. Specifically methylates 'Lys- 4' and 'Lys-5' of histone H3, inducing di- and tri-methylation, but not monomethylation. Plays an important role in transcriptional activation as a member of an RNA polymerase complex. Binds DNA containing 5'-CCCTCC-3' or 5'-GAGGGG-3' sequences (By similarity). |
Sequence Annotation | DOMAIN 4 240 SET.
ZN_FING 49 87 MYND-type.
REGION 14 16 S-adenosyl-L-methionine binding (By
REGION 205 206 S-adenosyl-L-methionine binding (By
BINDING 124 124 S-adenosyl-L-methionine (By similarity).
BINDING 132 132 S-adenosyl-L-methionine (By similarity).
BINDING 239 239 S-adenosyl-L-methionine (By similarity).
BINDING 259 259 S-adenosyl-L-methionine (By similarity). |
Keyword | Chromatin regulator; Complete proteome; Cytoplasm; Metal-binding; Methyltransferase; Nucleus; Reference proteome; S-adenosyl-L-methionine; Transferase; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 428 AA |
Protein Sequence | MEALKVEKFT TANRGNGLRA VAPLRPGELL FRSDPLAYTV CKGSRGVVCD RCLLGKEKLM 60
RCSQCRIAKY CSAKCQKKAW PDHRRECSCL KSCKPRYPPD SVRLLGRVIV KLMDEKPSES 120
EKLYSFYDLE SNISKLTEDK KEGLRQLAMT FQHFMREEIQ DASQLPPSFD LFEAFAKVIC 180
NSFTICNAEM QEVGVGLYPS MSLLNHSCDP NCSIVFNGPH LLLRAVREIE AGEELTICYL 240
DMLMTSEERR KQLRDQYCFE CDCIRCQTQD KDADMLTGDE QIWKEVQESL KKIEELKAHW 300
KWEQVLALCQ AIINSNSNRL PDINIYQLKV LDCAMDACIN LGMLEEALFY AMRTMEPYRI 360
FFPGSHPVRG VQVMKVGKLQ LHQGMFPQAM KNLRLAFDIM KVTHGREHSL IEDLILLLEE 420
CDANIRAS 428 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. GO:0018024; F:histone-lysine N-methyltransferase activity; IDA:UniProtKB. GO:0008270; F:zinc ion binding; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |