CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-003991
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Regulatory protein SIR4 
Protein Synonyms/Alias
 Silent information regulator 4 
Gene Name
 SIR4 
Gene Synonyms/Alias
 ASD1; STE9; UTH2; YDR227W; YD9934.12 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
1128TKKPLMVKNVKPSSPsumoylation[1]
Reference
 [1] A proteomic strategy for gaining insights into protein sumoylation in yeast.
 Denison C, Rudner AD, Gerber SA, Bakalarski CE, Moazed D, Gygi SP.
 Mol Cell Proteomics. 2005 Mar;4(3):246-54. [PMID: 15542864] 
Functional Description
 The proteins SIR1 through SIR4 are required for transcriptional repression of the silent mating type loci, HML and HMR. The proteins SIR2 through SIR4 repress mulitple loci by modulating chromatin structure. Involves the compaction of chromatin fiber into a more condensed form. 
Sequence Annotation
 MOD_RES 692 692 Phosphoserine.
 CROSSLNK 1128 1128 Glycyl lysine isopeptide (Lys-Gly)  
Keyword
 3D-structure; Coiled coil; Complete proteome; DNA-binding; Isopeptide bond; Nucleus; Phosphoprotein; Reference proteome; Repressor; Transcription; Transcription regulation; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1358 AA 
Protein Sequence
MPNDNKTPNR SSTPKFTKKP VTPNDKIPER EEKSNEVKTP KIPLFTFAKS KNYSRPSTAI 60
HTSPHQPSDV KPTSHKQLQQ PKSSPLKKNN YNSFPHSNLE KISNSKLLSL LRSKTSAGRI 120
ESNNPSHDAS RSLASFEQTA FSRHAQQQTS TFNSKPVRTI VPISTSQTNN SFLSGVKSLL 180
SEEKIRDYSK EILGINLANE QPVLEKPLKK GSADIGASVI SLTKDKSIRK DTVEEKKEEK 240
LNIGKNFAHS DSLSVPKVSA GDSGISPEES KARSPGIAKP NAIQTEVYGI NEESTNERLE 300
INQEKPVKLD ENSANSTVAS ALDTNGTSAT TETLTSKKIV PSPKKVAIDQ DKITLHDEKT 360
LAPSKHQPIT SEQKMKEDAD LKRMEILKSP HLSKSPADRP QGRRNSRNFS TRDEETTKLA 420
FLVEYEGQEN NYNSTSRSTE KKNDMNTSAK NKNGENKKIG KRPPEIMSTE AHVNKVTEET 480
TKQIQSVRID GRKVLQKVQG ESHIDSRNNT LNVTPSKRPQ LGEIPNPMKK HKPNEGRTPN 540
ISNGTINIQK KLEPKEIVRD ILHTKESSNE AKKTIQNPLN KSQNTALPST HKVTQKKDIK 600
IGTNDLFQVE SAPKISSEID RENVKSKDEP VSKAVESKSL LNLFSNVLKA PFIKSESKPF 660
SSDALSKEKA NFLETIASTE KPENKTDKVS LSQPVSASKH EYSDNFPVSL SQPSKKSFAN 720
HTEDEQIEKK KICRGRMNTI ITHPGKMELV YVSDSDDSSS DNDSLTDLES LSSGESNEIK 780
VTNDLDTSAE KDQIQAGKWF DPVLDWRKSD RELTKNILWR IADKTTYDKE TITDLIEQGI 840
PKHSYLSGNP LTSVTNDICS VENYETSSAF FYQQVHKKDR LQYLPLYAVS TFENTNNTEK 900
NDVTNKNINI GKHSQEQNSS SAKPSQIPTV SSPLGFEETK LSTTPTKSNR RVSHSDTNSS 960
KPKNTKENLS KSSWRQEWLA NLKLISVSLV DEFPSELSDS DRQIINEKMQ LLKDIFANNL 1020
KSAISNNFRE SDIIILKGEI EDYPMSSEIK IYYNELQNKP DAKKARFWSF MKTQRFVSNM 1080
GFDIQKSCEP VSISTSVKPH VVEPEHMADA KIMPKDILQI TKKPLMVKNV KPSSPPDVKS 1140
LVQLSTMETK TLPEKKQFDS IFNSNKAKII PGNGKHASEN ISLSFSRPAS YGYFSVGKRV 1200
PIVEDRRVKQ LDDITDSNTT EILTSVDVLG THSQTGTQQS NMYTSTQKTE LEIDNKDSVT 1260
ECSKDMKEDG LSFVDIVLSK AASALDEKEK QLAVANEIIR SLSDEVMRNE IRITSLQGDL 1320
TFTKKCLENA RSQISEKDAK INKLMEKDFQ VNKEIKPY 1358 
Gene Ontology
 GO:0005677; C:chromatin silencing complex; IDA:SGD.
 GO:0000783; C:nuclear telomere cap complex; IDA:SGD.
 GO:0005724; C:nuclear telomeric heterochromatin; IDA:SGD.
 GO:0003690; F:double-stranded DNA binding; IDA:SGD.
 GO:0042393; F:histone binding; TAS:SGD.
 GO:0031491; F:nucleosome binding; IDA:SGD.
 GO:0030527; F:structural constituent of chromatin; TAS:SGD.
 GO:0006342; P:chromatin silencing; IMP:SGD.
 GO:0006303; P:double-strand break repair via nonhomologous end joining; IDA:SGD.
 GO:0001308; P:negative regulation of chromatin silencing involved in replicative cell aging; IDA:SGD.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
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