CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-041041
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Plasma membrane calcium-transporting ATPase 2 
Protein Synonyms/Alias
  
Gene Name
 Atp2b2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
12TNSDFYSKNQRNESSubiquitination[1]
45RGTEAVVKIKETYGDubiquitination[1]
47TEAVVKIKETYGDTEubiquitination[1]
61EAICRRLKTSPVEGLubiquitination[1]
77GTAPDLEKRKQIFGQubiquitination[1]
191SRIEQEQKFTVVRAGubiquitination[1]
254QVRKSVDKDPMLLSGubiquitination[1]
349DSSQSKAKQQDGAAAubiquitination[1]
363AMEMQPLKSAEGGDAubiquitination[1]
476YSVKKMMKDNNLVRHubiquitination[1]
522YVGDVHYKEIPDPSSubiquitination[1]
557TKILPPEKEGALPRQubiquitination[1]
595RSQMPEEKLYKVYTFubiquitination[1]
598MPEEKLYKVYTFNSVubiquitination[1]
614KSMSTVIKMPDESFRubiquitination[1]
658RDRDEMVKKVIEPMAubiquitination[1]
659DRDEMVKKVIEPMACubiquitination[1]
744TARAIAIKCGIIHPGubiquitination[1]
760DFLCLEGKEFNRRIRubiquitination[1]
770NRRIRNEKGEIEQERubiquitination[1]
780IEQERIDKIWPKLRVubiquitination[1]
829TNDGPALKKADVGFAubiquitination[1]
830NDGPALKKADVGFAMubiquitination[1]
1101EAGRLTQKEEIPEEEubiquitination[1]
1157SLYEGLEKPESRTSIubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Hydrolase; Membrane; Nucleotide-binding; Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1243 AA 
Protein Sequence
MGDMTNSDFY SKNQRNESSH GGEFGCTMEE LRSLMELRGT EAVVKIKETY GDTEAICRRL 60
KTSPVEGLPG TAPDLEKRKQ IFGQNFIPPK KPKTFLQLVW EALQDVTLII LEIAAIISLG 120
LSFYHPPGES NEGCATAQGG AEDEGEAEAG WIEGAAILLS VICVVLVTAF NDWSKEKQFR 180
GLQSRIEQEQ KFTVVRAGQV VQIPVAEIVV GDIAQIKYGD LLPADGLFIQ GNDLKIDESS 240
LTGESDQVRK SVDKDPMLLS GTHVMEGSGR MVVTAVGVNS QTGIIFTLLG AGGEEEEKKD 300
KKGVKKGDGL QIPAADGAAP ANAAGSANAS LVNGKMQDGS ADSSQSKAKQ QDGAAAMEMQ 360
PLKSAEGGDA DDKKKANMHK KEKSVLQGKL TKLAVQIGKA GLVMSAITVI ILVLYFTVDT 420
FVVNKKPWLT ECTPVYVQYF VKFFIIGVTV LVVAVPEGLP LAVTISLAYS VKKMMKDNNL 480
VRHLDACETM GNATAICSDK TGTLTTNRMT VVQAYVGDVH YKEIPDPSSI NAKTLELLVN 540
AIAINSAYTT KILPPEKEGA LPRQVGNKTE CGLLGFVLDL RQDYEPVRSQ MPEEKLYKVY 600
TFNSVRKSMS TVIKMPDESF RMYSKGASEI VLKKCCKILS GAGEARVFRP RDRDEMVKKV 660
IEPMACDGLR TICVAYRDFP SSPEPDWDNE NDILNELTCI CVVGIEDPVR PEVPEAIRKC 720
QRAGITVRMV TGDNINTARA IAIKCGIIHP GEDFLCLEGK EFNRRIRNEK GEIEQERIDK 780
IWPKLRVLAR SSPTDKHTLV KGIIDSTHTE QRQVVAVTGD GTNDGPALKK ADVGFAMGIA 840
GTDVAKEASD IILTDDNFSS IVKAVMWGRN VYDSISKFLQ FQLTVNVVAV IVAFTGACIT 900
QDSPLKAVQM LWVNLIMDTF ASLALATEPP TETLLLRKPY GRNKPLISRT MMKNILGHAV 960
YQLTLIFTLL FVGEKMFQID SGRNAPLHSP PSEHYTIIFN TFVMMQLFNE INARKIHGER 1020
NVFDGIFRNP IFCTIVLGTF AIQIVIVQFG GKPFSCSPLQ LDQWMWCIFI GLGELVWGQV 1080
IATIPTSRLK FLKEAGRLTQ KEEIPEEELN EDVEEIDHAE RELRRGQILW FRGLNRIQTQ 1140
IRVVKAFRSS LYEGLEKPES RTSIHNFMAH PEFRIEDSQP HIPLIDDTDL EEDAALKQNS 1200
SPPSSLNKNN SAIDSGINLT TDTSKSATSS SPGSPIHSLE TSL 1243 
Gene Ontology
 GO:0016324; C:apical plasma membrane; IDA:MGI.
 GO:0005929; C:cilium; IDA:MGI.
 GO:0005783; C:endoplasmic reticulum; IDA:MGI.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0043025; C:neuronal cell body; IDA:MGI.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0030899; F:calcium-dependent ATPase activity; IMP:MGI.
 GO:0005388; F:calcium-transporting ATPase activity; IEA:InterPro.
 GO:0046872; F:metal ion binding; IEA:InterPro.
 GO:0060088; P:auditory receptor cell stereocilium organization; IMP:MGI.
 GO:0006816; P:calcium ion transport; IMP:MGI.
 GO:0006874; P:cellular calcium ion homeostasis; IMP:MGI.
 GO:0021707; P:cerebellar granule cell differentiation; IMP:MGI.
 GO:0021702; P:cerebellar Purkinje cell differentiation; IMP:MGI.
 GO:0046068; P:cGMP metabolic process; IMP:MGI.
 GO:0050910; P:detection of mechanical stimulus involved in sensory perception of sound; IMP:MGI.
 GO:0007595; P:lactation; IMP:MGI.
 GO:0040011; P:locomotion; IMP:MGI.
 GO:0007626; P:locomotory behavior; IMP:MGI.
 GO:0050885; P:neuromuscular process controlling balance; IMP:MGI.
 GO:0006996; P:organelle organization; IMP:MGI.
 GO:0045299; P:otolith mineralization; IMP:MGI.
 GO:0051928; P:positive regulation of calcium ion transport; IMP:MGI.
 GO:0008361; P:regulation of cell size; IMP:MGI.
 GO:0048167; P:regulation of synaptic plasticity; IMP:MGI.
 GO:0042428; P:serotonin metabolic process; IMP:MGI.
 GO:0050808; P:synapse organization; IMP:MGI. 
Interpro
 IPR022141; ATP_Ca_trans_C.
 IPR006408; ATPase_P-typ_Ca-transp_plasma.
 IPR006068; ATPase_P-typ_cation-transptr_C.
 IPR004014; ATPase_P-typ_cation-transptr_N.
 IPR023299; ATPase_P-typ_cyto_domN.
 IPR018303; ATPase_P-typ_P_site.
 IPR023298; ATPase_P-typ_TM_dom.
 IPR008250; ATPase_P-typ_transduc_dom_A.
 IPR001757; Cation_transp_P_typ_ATPase.
 IPR023214; HAD-like_dom. 
Pfam
 PF12424; ATP_Ca_trans_C
 PF00689; Cation_ATPase_C
 PF00690; Cation_ATPase_N
 PF00122; E1-E2_ATPase
 PF00702; Hydrolase 
SMART
 SM00831; Cation_ATPase_N 
PROSITE
 PS00154; ATPASE_E1_E2 
PRINTS
 PR00119; CATATPASE.