CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-020436
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Zinc finger CCHC domain-containing protein 2 
Protein Synonyms/Alias
  
Gene Name
 ZCCHC2 
Gene Synonyms/Alias
 KIAA1744 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
151YLRDSEAKANGLSDPubiquitination[1]
203PQVDSVLKSLRAARGubiquitination[1, 2, 3]
306EVEVEPCKFAGPRAQubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
  
Sequence Annotation
 ZN_FING 1131 1148 CCHC-type.
 MOD_RES 236 236 Phosphoserine.  
Keyword
 Complete proteome; Metal-binding; Phosphoprotein; Polymorphism; Reference proteome; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1178 AA 
Protein Sequence
MLRMKLPLKP THPAEPPPEA EEPEADARPG AKAPSRRRRD CRPPPPPPPP AGPSRGPLPP 60
PPPPRGLGPP VAGGAAAGAG MPGGGGGPSA ALREQERVYE WFGLVLGSAQ RLEFMCGLLD 120
LCNPLELRFL GSCLEDLARK DYHYLRDSEA KANGLSDPGP LADFREPAVR SRLIVYLALL 180
GSENREAAGR LHRLLPQVDS VLKSLRAARG EGSRGGAEDE RGEDGDGEQD AEKDGSGPEG 240
GIVEPRVGGG LGSRAQEELL LLFTMASLHP AFSFHQRVTL REHLERLRAA LRGGPEDAEV 300
EVEPCKFAGP RAQNNSAHGD YMQNNESSLI EQAPIPQDGL TVAPHRAQRE AVHIEKIMLK 360
GVQRKRADKY WEYTFKVNWS DLSVTTVTKT HQELQEFLLK LPKELSSETF DKTILRALNQ 420
GSLKREERRH PDLEPILRQL FSSSSQAFLQ SQKVHSFFQS ISSDSLHSIN NLQSSLKTSK 480
ILEHLKEDSS EASSQEEDVL QHAIIHKKHT GKSPIVNNIG TSCSPLDGLT MQYSEQNGIV 540
DWRKQSCTTI QHPEHCVTSA DQHSAEKRSL SSINKKKGKP QTEKEKIKKT DNRLNSRING 600
IRLSTPQHAH GGTVKDVNLD IGSGHDTCGE TSSESYSSPS SPRHDGRESF ESEEEKDRDT 660
DSNSEDSGNP STTRFTGYGS VNQTVTVKPP VQIASLGNEN GNLLEDPLNS PKYQHISFMP 720
TLHCVMHNGA QKSEVVVPAP KPADGKTIGM LVPSPVAISA IRESANSTPV GILGPTACTG 780
ESEKHLELLA SPLPIPSTFL PHSSTPALHL TVQRLKLPPP QGSSESCTVN IPQQPPGSLS 840
IASPNTAFIP IHNPGSFPGS PVATTDPITK SASQVVGLNQ MVPQIEGNTG TVPQPTNVKV 900
VLPAAGLSAA QPPASYPLPG SPLAAGVLPS QNSSVLSTAA TSPQPASAGI SQAQATVPPA 960
VPTHTPGPAP SPSPALTHST AQSDSTSYIS AVGNTNANGT VVPPQQMGSG PCGSCGRRCS 1020
CGTNGNLQLN SYYYPNPMPG PMYRVPSFFT LPSICNGSYL NQAHQSNGNQ LPFFLPQTPY 1080
ANGLVHDPVM GSQANYGMQQ MAGFGRFYPV YPAPNVVANT SGSGPKKNGN VSCYNCGVSG 1140
HYAQDCKQSS MEANQQGTYR LRYAPPLPPS NDTLDSAD 1178 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:LIFEdb.
 GO:0003676; F:nucleic acid binding; IEA:InterPro.
 GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0007154; P:cell communication; IEA:InterPro. 
Interpro
 IPR001683; Phox.
 IPR001878; Znf_CCHC. 
Pfam
 PF00098; zf-CCHC 
SMART
 SM00343; ZnF_C2HC 
PROSITE
 PS50158; ZF_CCHC 
PRINTS