CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016951
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 RNA-binding protein 45 
Protein Synonyms/Alias
 Developmentally-regulated RNA-binding protein 1; RB-1; RNA-binding motif protein 45 
Gene Name
 RBM45 
Gene Synonyms/Alias
 DRB1; DRBP1 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
170LGYVRYLKPSQAAQAubiquitination[1]
237SEFSSFDKNDSRGQEubiquitination[2]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
 RNA-binding protein with binding specificity for poly(C). May play an important role in neural development. 
Sequence Annotation
 DOMAIN 26 106 RRM 1.
 DOMAIN 121 195 RRM 2.
 DOMAIN 392 464 RRM 3.  
Keyword
 Alternative splicing; Complete proteome; Cytoplasm; Developmental protein; Differentiation; Neurogenesis; Nucleus; Reference proteome; Repeat; RNA-binding. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 476 AA 
Protein Sequence
MDEAGSSASG GGFRPGVDSL DEPPNSRIFL VISKYTPESV LRERFSPFGD IQDIWVVRDK 60
HTKESKGIAF VKFARSSQAC RAMEEMHGQC LGPNDTKPIK VFIAQSRSSG SHRDVEDEEL 120
TRIFVMIPKS YTEEDLREKF KVYGDIEYCS IIKNKVTGES KGLGYVRYLK PSQAAQAIEN 180
CDRSFRAILA EPKNKASESS EQDYYSNMRQ EALGHEPRVN MFPFVGEQQS EFSSFDKNDS 240
RGQEAISKRL SVVSRVPFTE EQLFSIFDIV PGLEYCEVQR DPYSNYGHGV VQYFNVASAI 300
YAKYKLHGFQ YPPGNRIGVS FIDDGSNATD LLRKMATQMV AAQLASMVWN NPSQQQFMQF 360
GGSSGSQLPQ IQTDVVLPSC KKKAPAETPV KERLFIVFNP HPLPLDVLED IFCRFGNLIE 420
VYLVSGKNVG YAKYADRISA NDAIATLHGK ILNGVRLKVM LADSPREESN KRQRTY 476 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:UniProtKB.
 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0003723; F:RNA binding; IDA:UniProtKB.
 GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
 GO:0007399; P:nervous system development; ISS:UniProtKB. 
Interpro
 IPR012677; Nucleotide-bd_a/b_plait.
 IPR000504; RRM_dom. 
Pfam
 PF00076; RRM_1 
SMART
 SM00360; RRM 
PROSITE
 PS50102; RRM 
PRINTS