UniProt Accession

 MDM12_YEAST; Q92328; D6W258; Q08064 

Genbank Protein ID

 U62252; Z74751; AY558013; BK006948 

Genbank Nucleotide ID

 AAB17867.1; CAA99008.1; AAS56339.1; DAA10774.1 

Protein Name

 Mitochondrial distribution and morphology protein 12 

Protein Synonyms/Alias

 Mitochondrial inheritance component MDM12 

Gene Name

 MDM12 

Gene Synonyms/Alias

 YOL009C 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
49	VLDFDLGKVGPAITL	ubiquitination	[1, 2]
85	TEENNDNKEDSEHIC	ubiquitination	[2]
198	NQTVLDPKGPILAAT	ubiquitination	[2]
206	GPILAATKPLERISI	ubiquitination	[2]

Reference

 [1] Sites of ubiquitin attachment in Saccharomyces cerevisiae.
 Starita LM, Lo RS, Eng JK, von Haller PD, Fields S.
 Proteomics. 2012 Jan;12(2):236-40. [PMID: 22106047]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

 Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis and may function in phospholipid exchange. MDM12 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10. The MDM12-MMM1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all mitochondrial outer membrane beta-barrel proteins, and acts in a late step after the SAM complex. The MDM10-MDM12-MMM1 subcomplex further acts in the TOM40-specific pathway after the action of the MDM12-MMM1 complex. Essential for establishing and maintaining the structure of mitochondria and maintenance of mtDNA nucleoids. 

Sequence Annotation

  

Keyword

 Complete proteome; Endoplasmic reticulum; Membrane; Mitochondrion; Mitochondrion outer membrane; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 271 AA 

Protein Sequence

Gene Ontology

 GO:0032865; C:ERMES complex; IPI:SGD.
 GO:0005634; C:nucleus; IDA:SGD.
 GO:0005886; C:plasma membrane; IDA:SGD.
 GO:0000002; P:mitochondrial genome maintenance; IEA:HAMAP.
 GO:0000001; P:mitochondrion inheritance; TAS:SGD.
 GO:0015914; P:phospholipid transport; IGI:SGD.
 GO:0045040; P:protein import into mitochondrial outer membrane; IMP:SGD. 

Interpro

 IPR027532; Mdm12. 

Pfam

  

SMART

  

PROSITE

  

PRINTS