CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038225
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Ethanolamine-phosphate phospho-lyase 
Protein Synonyms/Alias
  
Gene Name
 Agxt2l1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
23RHIGPSCKIFFAADPacetylation[1, 2, 3, 4]
32FFAADPIKIMRAQGQubiquitination[5]
45GQYMFDEKGERYLDCubiquitination[5]
66EVVKAAAKQMELLNTubiquitination[5]
87DNIIEFAKRLTATLPubiquitination[5]
171APDTYRGKYREDHEDubiquitination[5]
345MELLSEQKAKHPLIGubiquitination[5]
454AYRTKMPKEIQVELPubiquitination[5]
Reference
 [1] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758]
 [2] Circadian acetylome reveals regulation of mitochondrial metabolic pathways.
 Masri S, Patel VR, Eckel-Mahan KL, Peleg S, Forne I, Ladurner AG, Baldi P, Imhof A, Sassone-Corsi P.
 Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):3339-44. [PMID: 23341599]
 [3] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753]
 [4] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654]
 [5] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Pyridoxal phosphate; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 493 AA 
Protein Sequence
MCELYSKQDT LALRERHIGP SCKIFFAADP IKIMRAQGQY MFDEKGERYL DCINNVAHEV 60
VKAAAKQMEL LNTNSRFLHD NIIEFAKRLT ATLPQELSVC YFTNSGSEAN DLALRLARQF 120
RGHQDVITLD HAYHGHLSSL IEISPYKFQK GKDVKRETVH VAPAPDTYRG KYREDHEDPS 180
TAYADEVKKI IEEAHSSGRK IAAFIAESMQ SCGGQIIPPA GYFQKVAEHI HKAGGVFIAD 240
EVQVGFGRVG RYFWSFQMYG EDFVPDIVTM GKPMGNGHPI SCVVTTKEIA EAFSSSGMEY 300
FNTYGGNPVS CAVGLAVLDV IEKENLQGNA VRVGTYLMEL LSEQKAKHPL IGDIRGVGLF 360
IGIDLVKDRE KRTPATAEAQ HIIYEMKGKG VLLSADGPHR NVLKIKPPMC FTEDDAKFLV 420
DHLDGILTVL EEAMDSKSGT VFSENTAYRT KMPKEIQVEL PNLSATEARE IPRGKRNGVC 480
SDQQALLSKR LKT 493 
Gene Ontology
 GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
 GO:0008483; F:transaminase activity; IEA:InterPro.
 GO:0008152; P:metabolic process; IEA:GOC. 
Interpro
 IPR005814; Aminotrans_3.
 IPR015424; PyrdxlP-dep_Trfase.
 IPR015421; PyrdxlP-dep_Trfase_major_sub1.
 IPR015422; PyrdxlP-dep_Trfase_major_sub2. 
Pfam
 PF00202; Aminotran_3 
SMART
  
PROSITE
 PS00600; AA_TRANSFER_CLASS_3 
PRINTS