CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-019604
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Gamma-tubulin complex component 6 
Protein Synonyms/Alias
 GCP-6 
Gene Name
 TUBGCP6 
Gene Synonyms/Alias
 GCP6; KIAA1669 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
129PPQVLPRKRDYFLNNubiquitination[1]
137RDYFLNNKHVGRNVPubiquitination[2]
322AGRDAFDKFCRLHQGubiquitination[1]
669ELRMEIAKQELIAHAubiquitination[1]
710REQFQRLKEQFVKDQubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
 Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome. 
Sequence Annotation
 REPEAT 1027 1053 1.
 REPEAT 1054 1080 2.
 REPEAT 1081 1107 3.
 REPEAT 1108 1134 4.
 REPEAT 1135 1161 5.
 REPEAT 1162 1188 6.
 REPEAT 1189 1215 7.
 REPEAT 1216 1242 8.
 REPEAT 1243 1269 9.
 REGION 1027 1269 9 X 27 AA tandem repeats.  
Keyword
 Alternative splicing; Complete proteome; Cytoplasm; Cytoskeleton; Microtubule; Polymorphism; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1819 AA 
Protein Sequence
MASITQLFDD LCEALLPAAK THLGQRSVNR KRAKRSLKKV AYNALFTNLF QDETQQLQPD 60
MSKLPARNKI LMLSFDLRVG GLGPKADRLE ELVEELEAAP CCPLLEVGSV LDLLVQLAGS 120
GPPQVLPRKR DYFLNNKHVG RNVPYSGYDC DDLSVFEMDV QSLISREECL CHSMIQETLQ 180
VMEAAPGTGL PTVGLFSFGD PCGDRFERDT RVSLFGALVH SRTYDMDVRL GLPPVPDNAD 240
LSGLAIKVPP SVDQWEDEGF QSASNLTPDS QSEPSVTPDV DLWEAALTYE ASKRRCWERV 300
GCPPGHREEP YLTEAGRDAF DKFCRLHQGE LQLLAGGVLQ APQPVLVKEC ELVKDVLNVL 360
IGVVSATFSL CQPAQAFVVK RGVHVSGASP ESISSLLSEV AEYGTCYTRL SHFSLQPVLD 420
SLYSKGLVFQ AFTSGLRRYL QYYRACVLST PPTLSLLTIG FLFKKLGRQL RYLAELCGVG 480
AVLPGTCGGG PRAAFPTGVK LLSYLYQEAL HNCSNEHYPV LLSLLKTSCE PYTRFIHDWV 540
YSGVFRDAYG EFMIQVNHEY LSFRDKLYWT HGYVLISKEV EDCVPVFLKH IAHDIYVCGK 600
TINLLKLCCP RHYLCWSDVP VPRISVIFSL EELKEIEKDC AVYVGRMERV ARHSSVSKEE 660
KELRMEIAKQ ELIAHAREAA SRVLSALSDR QMSERMALDA RKREQFQRLK EQFVKDQERR 720
QAARQEELDD DFSYARELRD RERRLKSLEE ELERKARQAL VDHYSKLSAE AARREQKALW 780
RIQRHRLESA RLRFLLEDEK HIQEMLKAVS EAHQPQEPPD VLLSVHPQVT SPGPEHPEGG 840
QGCDSGSAEQ HSPAWDGWNR PGLLTPQPLK PLAVGAGGRG LQQAEGARPF SDSLSIGDFL 900
PVGPGAEPSV QTGMVPLLEV ALQTINLDLP PSAPGEAPAA ASTQPSRPQE YDFSTVLRPA 960
VATSPAPGPL QAAECSLGSS GLQLWEDSCG KMDACGSASR ETLLPSHPPR RAALEEGSSQ 1020
PTERLFGQVS GGGLPTGDYA SEIAPTRPRW NTHGHVSDAS IRVGENVSDV APTQPRWNTH 1080
GHVSNASISL GESVSDVAPT RPRWNIHGHV SNASIRVGEN VSDVAPTRPR WNTHGHVSNA 1140
SIRVGENVSD VAPTRPRWNT HGHVSDASIS LGESVSDMAP ARPRWNTHGH VSDASISLGE 1200
SVSDMAPTRP RWNTHGHVSD TSIRVGENVS DVAPIRSRCN THGHVSDASI SLGEPVSDVV 1260
STRPRWNTHV PIPPPHMVLG ALSPEAEPNT PRPQQSPPGH TSQSALSLGA QSTVLDCGPR 1320
LPVEVGPSLS SPSSGCGEGS ISVGENVSDV APTQPWWPNT PGDSVSEELG PGRSGDTEDL 1380
SPNWPLNSQE DTAAQSSPGR GEEAEASAAE AQGGEQAYLA GLAGQYHLER YPDSYESMSE 1440
PPIAHLLRPV LPRAFAFPVD PQVQSAADET AVQLSELLTL PVLMKRSITA PLAAHISLVN 1500
KAAVDYFFVE LHLEAHYEAL RHFLLMEDGE FAQSLSDLLF EKLGAGQTPG ELLNPLVLNS 1560
VLSKALQCSL HGDTPHASNL SLALKYLPEV FAPNAPDVLS CLELRYKVDW PLNIVITEGC 1620
VSKYSGVFSF LLQLKLMMWA LKDVCFHLKR TALLSHMAGS VQFRQLQLFK HEMQHFVKVI 1680
QGYIANQILH VTWCEFRARL ATVGDLEEIQ RAHAEYLHKA VFRGLLTEKA APVMNVIHSI 1740
FSLVLKFRSQ LISQAWGPPG GPRGAEHPNF ALMQQSYNTF KYYSHFLFKV VTKLVNRGYQ 1800
PHLEDFLLRI NFNNYYQDA 1819 
Gene Ontology
 GO:0005813; C:centrosome; IDA:UniProtKB.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0008274; C:gamma-tubulin ring complex; IDA:UniProtKB.
 GO:0005874; C:microtubule; IEA:UniProtKB-KW.
 GO:0000922; C:spindle pole; IEA:InterPro.
 GO:0008017; F:microtubule binding; IDA:UniProtKB.
 GO:0000086; P:G2/M transition of mitotic cell cycle; TAS:Reactome.
 GO:0007020; P:microtubule nucleation; IDA:UniProtKB. 
Interpro
 IPR007259; Spc97_Spc98. 
Pfam
 PF04130; Spc97_Spc98 
SMART
  
PROSITE
  
PRINTS