CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-040067
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Pogo transposable element with ZNF domain 
Protein Synonyms/Alias
  
Gene Name
 POGZ 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
163HVPRKSPKYLALFKNacetylation[1]
163HVPRKSPKYLALFKNubiquitination[2]
415NEETLFQKATKIGRSubiquitination[3]
418TLFQKATKIGRSLEGubiquitination[3]
585HTACQRSKGMLVMDCubiquitination[3]
631QPLDVCIKRTVKNFLubiquitination[3]
Reference
 [1] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 772 AA 
Protein Sequence
MRHQKRNVYH CNKCRLQFLF AKDKIEHKLQ HHKTFRKPKQ LEGLKPGTKV TIRASRGQPR 60
TVPVSSNDTP PSALQEAAPL TSSMDPLPVF LYPPVQRSIQ KRAVRKMSVM GRQTCLECSF 120
EIPDFPNHFP TYVHCSLCRY STCCSRAYAN HMINNHVPRK SPKYLALFKN SVSGIKLACT 180
SCTFVTSVGD AMAKHLVFNP SHRSSSILPR GLTWIAHSRH GQTRDRVHDR NVKNMYPPPS 240
FPTNKAATVK SAGATPAEPE ELLTPLAPAL PSPASTATPP PTPTHPQALA LPPLATEGAE 300
CLNVDDQDEG SPVTQEPELA SGGGGSGGVG KKEQLSVKKL RVVLFALCCN TEQAAEHFRN 360
PQRRIRRWLR RFQASQGENL EGKYLSFEAE EKLAEWVLTQ REQQLPVNEE TLFQKATKIG 420
RSLEGGFKIS YEWAVRFMLR HHLTPHARRA VAHTLPKDVA ENAGLFIDFV QRQIHNQDLP 480
LSMIVAIDEI SLFLDTEVLS SDDRKENALQ TVGTGEPWCD VVLAILADGT VLPTLVFYRG 540
QMDQPANMPD SILLEAKESG YSDDEIMELW STRVWQKHTA CQRSKGMLVM DCHRTHLSEE 600
VLAMLSASST LPAVVPAGCS SKIQPLDVCI KRTVKNFLHK KWKEQAREMA DTACDSDVLL 660
QLVLVWLGEV LGVIGDCPEL VQRSFLVASV LPGPDGNINS PTRNADMQEE LIASLEEQLK 720
LSGEHSESST PRPRSSPEET IEPESLHQLF EGESETESFY GFEEADLDLM EI 772 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0003677; F:DNA binding; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro. 
Interpro
 IPR004875; DDE_SF_endonuclease_CENPB-like.
 IPR009057; Homeodomain-like.
 IPR006600; HTH_CenpB_DNA-bd_dom.
 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like. 
Pfam
 PF03184; DDE_1
 PF03221; HTH_Tnp_Tc5 
SMART
 SM00674; CENPB
 SM00355; ZnF_C2H2 
PROSITE
 PS51253; HTH_CENPB
 PS00028; ZINC_FINGER_C2H2_1 
PRINTS