UniProt Accession

 F6RIS4_HUMAN; F6RIS4 

Genbank Protein ID

 AL138842; AL160282 

Genbank Nucleotide ID

  

Protein Name

 Thioredoxin-interacting protein 

Protein Synonyms/Alias

  

Gene Name

 TXNIP 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
41	VIMRPGNKYEYKFGF	ubiquitination	[1]
45	PGNKYEYKFGFELPQ	ubiquitination	[1]
60	GPLGTSFKGKYGCVD	ubiquitination	[1, 2, 3]
108	LMAPVSAKKEKKVSC	ubiquitination	[1]
157	CSRIVVPKAAIVARH	ubiquitination	[1, 2, 3]
173	YLANGQTKVLTQKLS	ubiquitination	[1, 2]
178	QTKVLTQKLSSVRGN	ubiquitination	[2, 3]
232	VSVPGSKKVILDLPL	ubiquitination	[1, 2]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 304 AA 

Protein Sequence

Gene Ontology

  

Interpro

 IPR011021; Arrestin-like_N.
 IPR011022; Arrestin_C-like.
 IPR014756; Ig_E-set. 

Pfam

 PF02752; Arrestin_C
 PF00339; Arrestin_N 

SMART

 SM01017; Arrestin_C 

PROSITE

  

PRINTS