UniProt Accession

 B4GT3_HUMAN; O60512; D3DVG3; O60910; Q9BPZ4; Q9H8T2 

Genbank Protein ID

 Y12509; AF038661; AB024435; AL590714; AK023311; CH471121; CH471121; CH471121; CH471121; CH471121; BC000276; BC006099; BC009985 

Genbank Nucleotide ID

 CAA73111.1; AAC39734.1; BAA75820.1; CAH72145.1; BAB14520.1; EAW52628.1; EAW52629.1; EAW52630.1; EAW52631.1; EAW52632.1; AAH00276.1; AAH06099.1; AAH09985.1 

Protein Name

 Beta-1,4-galactosyltransferase 3 

Protein Synonyms/Alias

 Beta-1,4-GalTase 3; Beta4Gal-T3; b4Gal-T3; UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 3; UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 3; N-acetyllactosamine synthase; Nal synthase; Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase; Beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase 

Gene Name

 B4GALT3 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
173	NGTFNRAKLLNVGVR	ubiquitination	[1, 2]
275	RVRLAGMKISRPPTS	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

 Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. 

Sequence Annotation

 METAL 197 197 Manganese (By similarity).
 METAL 291 291 Manganese (By similarity).
 CARBOHYD 57 57 N-linked (GlcNAc...) (Potential).
 CARBOHYD 166 166 N-linked (GlcNAc...) (Potential).
 CARBOHYD 337 337 N-linked (GlcNAc...) (Potential).
 CARBOHYD 385 385 N-linked (GlcNAc...) (Potential).
 DISULFID 77 119 By similarity.
 DISULFID 190 209 By similarity.  

Keyword

 Alternative splicing; Complete proteome; Disulfide bond; Glycoprotein; Glycosyltransferase; Golgi apparatus; Manganese; Membrane; Metal-binding; Reference proteome; Signal-anchor; Transferase; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 393 AA 

Protein Sequence

Gene Ontology

 GO:0032580; C:Golgi cisterna membrane; IEA:UniProtKB-SubCell.
 GO:0000139; C:Golgi membrane; TAS:Reactome.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0003831; F:beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity; IEA:EC.
 GO:0008378; F:galactosyltransferase activity; TAS:ProtInc.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0003945; F:N-acetyllactosamine synthase activity; IEA:EC.
 GO:0018146; P:keratan sulfate biosynthetic process; TAS:Reactome.
 GO:0043687; P:post-translational protein modification; TAS:Reactome.
 GO:0018279; P:protein N-linked glycosylation via asparagine; TAS:Reactome. 

Interpro

 IPR003859; Galactosyl_T_2_met. 

Pfam

 PF02709; Glyco_transf_7C 

SMART

  

PROSITE

  

PRINTS

 PR02050; B14GALTRFASE.