CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-045203
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Agrin 
Protein Synonyms/Alias
  
Gene Name
 Agrn 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
79VWRYLKGKDVVAQESacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Disulfide bond; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2034 AA 
Protein Sequence
MVRPRLSFPA PLLPLLLLLA AAAPAVPGAS GTCPERALER REEEANVVLT GTVEEILNVD 60
PVQHTYSCKV RVWRYLKGKD VVAQESLLDG GNKVVIGGFG DPLICDNQVS TGDTRIFFVN 120
PAPPYLWPAH KNELMLNSSL MRITLRNLEE VEFCVEDKPG IHFTAAPSMP PDVCRGMLCG 180
FGAVCEPSVE DPGRASCVCK KNVCPAMVAP VCGSDASTYS NECELQRAQC NQQRRIRLLR 240
QGPCGSRDPC ANVTCSFGST CVPSADGQTA SCLCPTTCFG APDGTVCGSD GVDYPSECQL 300
LRHACANQEH IFKKFDGPCD PCQGSMSDLN HICRVNPRTR HPEMLLRPEN CPAQHTPICG 360
DDGVTYENDC VMSRIGAARG LLLQKVRSGQ CQTRDQCPET CQFNSVCLSR RGRPHCSCDR 420
VTCDGAYRPV CAQDGHTYDN DCWRQQAECR QQQTIPPKHQ GPCDQTPSPC RGAQCAFGAT 480
CTVKNGKAVC ECQRVCSGGY DPVCGSDGVT YGSVCELESM ACTLGREIRV ARRGPCDRCG 540
QCRFGSLCEV ETGRCVCPSE CVESAQPVCG SDGHTYASEC ELHVHACTHQ ISLYVASAGH 600
CQTCGETVCT FGAVCSAGQC VCPRCEHPPP GPVCGSDGVT YLSACELREA ACQQQVQIEE 660
ARAGPCEPAE CGSGGSGSGE DNACEQELCR QHGGVWDEDS EDGPCVCDFS CQSVLKSPVC 720
GSDGVTYSTE CHLKKARCEA RQELYVAAQG ACRGPTLAPL LPMASPHCAQ TPYGCCQDNV 780
TAAQGVGLAG CPSTCHCNPH GSYSGTCDPV TGQCSCRPGV GGLRCDRCEP GFWNFRGIVT 840
DGHSGCTPCS CDPRGAVRDD CEQMTGLCSC RPGVAGPKCG QCPDGQALGH LGCEADPTTP 900
VTCVEMHCEF GASCVEEAGF AQCVCPTLTC PEANSTKVCG SDGVTYGNEC QLKTIACRQR 960
LDISIQSLGP CRESVAPGVS PTSASMTTPR HILSRTLASP HSSLPLSPST TAHDWPTPLP 1020
TSPQTVVGTP RSTAATPSDV ASLATAIFRE SGSTNGSGDE ELSGDEEASG GGSGGLEPPV 1080
GSVVVTHGPP IERASCYNSP LGCCSDGKTP SLDSEGSNCP ATKAFQGVLE LEGVEGQELF 1140
YTPEMADPKS ELFGETARSI ESTLDDLFRN SDVKKDFWSI RLRELGPGKL VRAIVDVHFD 1200
PTTAFQAPDV GQALLQQIQV SRPWALAVRR PLREHVRFLD FDWFPTFFTG AATGTTAAVA 1260
TARATTVSRL SASSVTPRVY PSYTSRPVGR TTAPLTTRRP PTTTASIDRP RTPGPQRPPK 1320
SCDSQPCLHG GTCQDLDSGK GFSCSCTAGR AGTVCEKVQL PSVPAFKGHS FLAFPTLRAY 1380
HTLRLALEFR ALETEGLLLY NGNARGKDFL ALALLDGHVQ FRFDTGSGPA VLTSLVPVEP 1440
GRWHRLELSR HWRQGTLSVD GEAPVVGESP SGTDGLNLDT KLYVGGLPEE QVATVLDRTS 1500
VGIGLKGCIR MLDINNQQLE LSDWQRAVVQ SSGVGECGDH PCSPNPCHGG ALCQALEAGV 1560
FLCQCPPGRF GPTCADEKNP CQPNPCHGSA PCHVLSRGGA KCACPLGRSG SFCETVLENA 1620
GSRPFLADFN GFSYLELKGL HTFERDLGEK MALEMVFLAR GPSGLLLYNG QKTDGKGDFV 1680
SLALHNRHLE FRYDLGKGAA IIRSKEPIAL GTWVRVFLER NGRKGALQVG DGPRVLGESP 1740
VPHTMLNLKE PLYVGGAPDF SKLARGAAVA SGFDGAIQLV SLRGHQLLTQ EHVLRAVDVA 1800
PFAGHPCTQA VDNPCLNGGS CIPREATYEC LCPGGFSGLH CEKGIVEKSV GDLETLAFDG 1860
RTYIEYLNAV TESEKALQSN HFELSLRTEA TQGLVLWIGK VGERADYMAL AIVDGHLQLS 1920
YDLGSQPVVL RSTVKVNTNR WLRVRAHREH REGSLQVGNE APVTGSSPLG ATQLDTDGAL 1980
WLGGLQKLPV GQALPKAYGT GFVGCLRDVV VGHRQLHLLE DAVTKPELRP CPTL 2034 
Gene Ontology
 GO:0005605; C:basal lamina; IDA:MGI.
 GO:0009986; C:cell surface; IDA:MGI.
 GO:0005615; C:extracellular space; IDA:MGI.
 GO:0045202; C:synapse; IDA:MGI.
 GO:0030548; F:acetylcholine receptor regulator activity; IDA:MGI.
 GO:0007213; P:G-protein coupled acetylcholine receptor signaling pathway; IEA:InterPro.
 GO:0007528; P:neuromuscular junction development; IGI:MGI.
 GO:0045213; P:neurotransmitter receptor metabolic process; IDA:MGI.
 GO:0007009; P:plasma membrane organization; IMP:MGI.
 GO:0043525; P:positive regulation of neuron apoptotic process; IMP:MGI.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:MGI.
 GO:0043113; P:receptor clustering; IDA:MGI.
 GO:0008582; P:regulation of synaptic growth at neuromuscular junction; IMP:MGI. 
Interpro
 IPR004850; Agrin_NtA.
 IPR008985; ConA-like_lec_gl_sf.
 IPR013320; ConA-like_subgrp.
 IPR000742; EG-like_dom.
 IPR013032; EGF-like_CS.
 IPR002049; EGF_laminin.
 IPR003645; Fol_N.
 IPR002350; Kazal_dom.
 IPR001791; Laminin_G.
 IPR000082; SEA_dom.
 IPR008993; TIMP-like_OB-fold. 
Pfam
 PF00008; EGF
 PF00050; Kazal_1
 PF07648; Kazal_2
 PF00053; Laminin_EGF
 PF00054; Laminin_G_1
 PF03146; NtA
 PF01390; SEA 
SMART
 SM00181; EGF
 SM00180; EGF_Lam
 SM00274; FOLN
 SM00280; KAZAL
 SM00282; LamG
 SM00200; SEA 
PROSITE
 PS00022; EGF_1
 PS01186; EGF_2
 PS50026; EGF_3
 PS01248; EGF_LAM_1
 PS50027; EGF_LAM_2
 PS51465; KAZAL_2
 PS50025; LAM_G_DOMAIN
 PS51121; NTA
 PS50024; SEA 
PRINTS