UniProt Accession

 GBRL1_HUMAN; Q9H0R8; B4E0Y7; Q6FIE6 

Genbank Protein ID

 AF287012; AF087847; JN663881; AL136676; AK303581; CR533480; AC115676; CH471094; BC009309; BC028315 

Genbank Nucleotide ID

 AAK55962.1; AAK20399.1; AEZ06294.1; CAB66611.1; BAG64599.1; CAG38511.1; EAW96164.1; AAH09309.1; AAH28315.1 

Protein Name

 Gamma-aminobutyric acid receptor-associated protein-like 1 

Protein Synonyms/Alias

 Early estrogen-regulated protein; GABA(A) receptor-associated protein-like 1; Glandular epithelial cell protein 1; GEC-1 

Gene Name

 GABARAPL1 

Gene Synonyms/Alias

 GEC1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
24	EGEKIRKKYPDRVPV	ubiquitination	[1]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 

Functional Description

 Ubiquitin-like modifier that increases cell-surface expression of kappa-type opioid receptor through facilitating anterograde intracellular trafficking of the receptor. Involved in formation of autophagosomal vacuoles. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. 

Sequence Annotation

 REGION 1 22 Interaction with beta-tubulin (By
 REGION 36 68 Interaction with GABRG2 (By similarity).
 LIPID 116 116 Phosphatidylethanolamine amidated glycine  

Keyword

 3D-structure; Alternative splicing; Autophagy; Complete proteome; Cytoplasm; Cytoplasmic vesicle; Cytoskeleton; Endoplasmic reticulum; Golgi apparatus; Lipoprotein; Membrane; Microtubule; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 117 AA 

Protein Sequence

Gene Ontology

 GO:0005776; C:autophagic vacuole; IDA:MGI.
 GO:0044297; C:cell body; IEA:Compara.
 GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
 GO:0032839; C:dendrite cytoplasm; IEA:Compara.
 GO:0032590; C:dendrite membrane; IEA:Compara.
 GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
 GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
 GO:0005874; C:microtubule; IEA:UniProtKB-KW.
 GO:0048487; F:beta-tubulin binding; ISS:UniProtKB.
 GO:0050811; F:GABA receptor binding; ISS:UniProtKB.
 GO:0006914; P:autophagy; IEA:UniProtKB-KW. 

Interpro

 IPR004241; Atg8_ubiquitin-like. 

Pfam

 PF02991; Atg8 

SMART

  

PROSITE

  

PRINTS