| Tag | Content |
|---|
| CPLM ID | CPLM-004262 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Carbamoyl-phosphate synthase large chain |
Protein Synonyms/Alias | Carbamoyl-phosphate synthetase ammonia chain |
Gene Name | carB |
Gene Synonyms/Alias | STM0067 |
Created Date | July 27, 2013 |
Organism | Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) |
NCBI Taxa ID | 99287 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 504 | FADARLAKLAGVREA | acetylation | [1] |
|
Reference | [1] Regulation of cellular metabolism by protein lysine acetylation. Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL. Science. 2010 Feb 19;327(5968):1000-4. [ PMID: 20167786] |
Functional Description | |
Sequence Annotation | DOMAIN 133 328 ATP-grasp 1.
DOMAIN 679 870 ATP-grasp 2.
NP_BIND 159 216 ATP (By similarity).
NP_BIND 705 762 ATP (By similarity).
REGION 2 403 Carboxyphosphate synthetic domain.
REGION 404 553 Oligomerization domain.
REGION 554 936 Carbamoyl phosphate synthetic domain.
REGION 937 1075 Allosteric domain.
METAL 285 285 Magnesium or manganese 1 (By similarity).
METAL 299 299 Magnesium or manganese 1 (By similarity).
METAL 299 299 Magnesium or manganese 2 (By similarity).
METAL 301 301 Magnesium or manganese 2 (By similarity).
METAL 829 829 Magnesium or manganese 3 (By similarity).
METAL 841 841 Magnesium or manganese 3 (By similarity).
METAL 841 841 Magnesium or manganese 4 (By similarity).
METAL 843 843 Magnesium or manganese 4 (By similarity). |
Keyword | Amino-acid biosynthesis; Arginine biosynthesis; ATP-binding; Complete proteome; Ligase; Magnesium; Manganese; Metal-binding; Nucleotide-binding; Pyrimidine biosynthesis; Reference proteome; Repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1075 AA |
Protein Sequence | MPKRTDIKSI LILGAGPIVI GQACEFDYSG AQACKALREE GYRVILVNSN PATIMTDPEM 60
ADATYIEPIH WEVVRKIIEK ERPDAVLPTM GGQTALNCAL ELERQGVLEE FGVTMIGATA 120
DAIDKAEDRR RFDIAMKKIG LDTARSGIAH TMEEALAVAA DVGFPCIIRP SFTMGGTGGG 180
IAYNREEFEE ICERGLDLSP TNELLIDESL IGWKEYEMEV VRDKNDNCII VCSIENFDAM 240
GIHTGDSITV APAQTLTDKE YQIMRNASMA VLREIGVETG GSNVQFAVNP KNGRLIVIEM 300
NPRVSRSSAL ASKATGFPIA KVAAKLAVGY TLDELMNDIT GGRTPASFEP SIDYVVTKIP 360
RFNFEKFAGA NDRLTTQMKS VGEVMAIGRT QQESLQKALR GLEVGATGFD PKVSLDDPEA 420
LTKIRRELKD AGADRIWYIA DAFRAGLSVD GVFNLTNIDR WFLVQIEELV RLEEKVAEVG 480
ITGLNADFLR QLKRKGFADA RLAKLAGVRE AEIRKLRDQY DLHPVYKRVD TCAAEFATDT 540
AYMYSTYEDE CEANPSIDRD KIMVLGGGPN RIGQGIEFDY CCVHASLALR EDGYETIMVN 600
CNPETVSTDY DTSDRLYFEP VTLEDVLEIV RIEKPKGVIV QYGGQTPLKL ARALEAAGVP 660
VIGTSPDAID RAEDRERFQH AVDRLKLKQP ANATVTAIEQ AVEKAKEIGY PLVVRPSYVL 720
GGRAMEIVYD EADLRRYFQT AVSVSNDAPV LLDRFLDDAV EVDVDAICDG EMVLIGGIME 780
HIEQAGVHSG DSACSLPAYT LSQEIQDVMR QQVQKLAFEL QVRGLMNVQF AVKDNEVYLI 840
EVNPRAARTV PFVSKATGVP LAKVAARVMA GKSLTEQGVT QEIIPPYYSV KEVVLPFNKF 900
PGVDPLLGPE MRSTGEVMGV GRTFAEAFAK AQLGSNSTMK KQGRALLSVR EGDKERVVDL 960
AAKLLKQGFE LDATHGTAIV LGEAGINPRL VNKVHEGRPH IQDRIKNGEY TYIINTTAGR 1020
RAIEDSRVIR RSALQYKVHY DTTLNGGFAT TMALNADATE KVTSVQEMHA QIKKS 1075 |
Gene Ontology | GO:0005524; F:ATP binding; IEA:HAMAP. GO:0004088; F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity; IEA:HAMAP. GO:0000287; F:magnesium ion binding; IEA:HAMAP. GO:0030145; F:manganese ion binding; IEA:HAMAP. GO:0044205; P:'de novo' UMP biosynthetic process; IEA:UniProtKB-UniPathway. GO:0006526; P:arginine biosynthetic process; IEA:HAMAP. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |