CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-020867
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Junctional adhesion molecule C 
Protein Synonyms/Alias
 JAM-C; JAM-2; Junctional adhesion molecule 3; JAM-3 
Gene Name
 Jam3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
287ESYKSPGKHDGVNYIubiquitination[1]
305EEGDFRHKSSFVI**ubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Participates in cell-cell adhesion. It is a counter- receptor for ITGAM mediating leukocyte-platelet interactions and is involved in the regulation of transepithelial migration of polymorphonuclear neutrophils (PMN) (By similarity). The soluble form is a mediator of angiogenesis. 
Sequence Annotation
 DOMAIN 35 127 Ig-like V-type.
 DOMAIN 139 236 Ig-like C2-type.
 CARBOHYD 104 104 N-linked (GlcNAc...) (Potential).
 CARBOHYD 192 192 N-linked (GlcNAc...).
 CARBOHYD 198 198 N-linked (GlcNAc...); atypical.
 DISULFID 53 115 Potential.
 DISULFID 160 219 Potential.  
Keyword
 Angiogenesis; Cell adhesion; Cell junction; Cell membrane; Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; Immunoglobulin domain; Membrane; Reference proteome; Secreted; Signal; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 310 AA 
Protein Sequence
MALSRRLRLR LYARLPDFFL LLLFRGCMIE AVNLKSSNRN PVVHEFESVE LSCIITDSQT 60
SDPRIEWKKI QDGQTTYVYF DNKIQGDLAG RTDVFGKTSL RIWNVTRSDS AIYRCEVVAL 120
NDRKEVDEIT IELIVQVKPV TPVCRIPAAV PVGKTATLQC QESEGYPRPH YSWYRNDVPL 180
PTDSRANPRF QNSSFHVNSE TGTLVFNAVH KDDSGQYYCI ASNDAGAARC EGQDMEVYDL 240
NIAGIIGGVL VVLIVLAVIT MGICCAYRRG CFISSKQDGE SYKSPGKHDG VNYIRTSEEG 300
DFRHKSSFVI 310 
Gene Ontology
 GO:0009986; C:cell surface; ISA:MGI.
 GO:0044291; C:cell-cell contact zone; IEA:Compara.
 GO:0030057; C:desmosome; ISS:UniProtKB.
 GO:0005615; C:extracellular space; ISS:UniProtKB.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0033010; C:paranodal junction; IDA:MGI.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0043220; C:Schmidt-Lanterman incisure; IDA:MGI.
 GO:0005923; C:tight junction; IDA:MGI.
 GO:0002250; P:adaptive immune response; IMP:MGI.
 GO:0001525; P:angiogenesis; IDA:UniProtKB.
 GO:0007160; P:cell-matrix adhesion; IDA:MGI.
 GO:0030010; P:establishment of cell polarity; IDA:MGI.
 GO:0002523; P:leukocyte migration involved in inflammatory response; IMP:MGI.
 GO:0042552; P:myelination; IMP:MGI.
 GO:0002318; P:myeloid progenitor cell differentiation; IMP:MGI.
 GO:0001780; P:neutrophil homeostasis; IMP:MGI.
 GO:0090138; P:regulation of actin cytoskeleton organization by cell-cell adhesion; IMP:MGI.
 GO:0090022; P:regulation of neutrophil chemotaxis; ISS:UniProtKB.
 GO:0007286; P:spermatid development; IMP:MGI. 
Interpro
 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR013098; Ig_I-set.
 IPR003599; Ig_sub.
 IPR003598; Ig_sub2.
 IPR013106; Ig_V-set. 
Pfam
 PF07679; I-set
 PF07686; V-set 
SMART
 SM00409; IG
 SM00408; IGc2 
PROSITE
 PS50835; IG_LIKE 
PRINTS