CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-044202
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Active breakpoint cluster region-related protein 
Protein Synonyms/Alias
  
Gene Name
 ABR 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
102KAFVDNYKVALETAEubiquitination[1]
110VALETAEKCSQSNNQubiquitination[1]
120QSNNQFQKISEELKVubiquitination[1]
126QKISEELKVKGPKDSubiquitination[1]
148TMEALLYKPIDRVTRubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 168 AA 
Protein Sequence
MRKLVLSGFL ASEEIYINQL EALLLPMKPL KATATTSQPV LTIQQIETIF YKIQDIYEIH 60
KEFYDNLCPK VQQWDSQVTM GHLFQKLASQ LGVYKAFVDN YKVALETAEK CSQSNNQFQK 120
ISEELKVKGP KDSKDSHTSV TMEALLYKPI DRVTRSTLVL HDLLKHTP 168 
Gene Ontology
 GO:0005829; C:cytosol; IEA:Compara.
 GO:0005886; C:plasma membrane; IEA:Compara.
 GO:0030675; F:Rac GTPase activator activity; IEA:Compara.
 GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
 GO:0030036; P:actin cytoskeleton organization; IEA:Compara.
 GO:0007420; P:brain development; IEA:Compara.
 GO:0042472; P:inner ear morphogenesis; IEA:Compara.
 GO:0035556; P:intracellular signal transduction; IEA:InterPro.
 GO:0030336; P:negative regulation of cell migration; IEA:Compara.
 GO:0050728; P:negative regulation of inflammatory response; IEA:Compara.
 GO:0043314; P:negative regulation of neutrophil degranulation; IEA:Compara.
 GO:0050885; P:neuromuscular process controlling balance; IEA:Compara.
 GO:0050766; P:positive regulation of phagocytosis; IEA:Compara.
 GO:0032496; P:response to lipopolysaccharide; IEA:Compara. 
Interpro
 IPR000219; DH-domain.
 IPR001331; GDS_CDC24_CS. 
Pfam
 PF00621; RhoGEF 
SMART
 SM00325; RhoGEF 
PROSITE
 PS00741; DH_1
 PS50010; DH_2 
PRINTS