| Tag | Content |
|---|
| CPLM ID | CPLM-014204 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | U4/U6.U5 tri-snRNP-associated protein 1 |
Protein Synonyms/Alias | Squamous cell carcinoma antigen recognized by T-cells 1; SART-1; rSART-1 |
Gene Name | Sart1 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 219 | KEKDLAEKRAKLLEE | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Plays a role in mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the spliceosome. May also bind to DNA. |
Sequence Annotation | MOD_RES 431 431 Phosphothreonine (By similarity).
MOD_RES 527 527 Phosphoserine (By similarity).
MOD_RES 597 597 Phosphoserine (By similarity).
MOD_RES 602 602 Phosphoserine (By similarity).
MOD_RES 604 604 Phosphoserine (By similarity).
MOD_RES 701 701 Phosphothreonine (By similarity).
MOD_RES 770 770 Phosphothreonine (By similarity). |
Keyword | Coiled coil; Complete proteome; mRNA processing; mRNA splicing; Nucleus; Phosphoprotein; Reference proteome; Spliceosome; Ubl conjugation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 806 AA |
Protein Sequence | MGSSKKHRGE KEAAGTTAAA GTGGTTEQPP RHREHKKHKH RSSGGGSSGG ERRKRSRERG 60
AERGSGRRGA EAEARSGAHG RERSQAEPSE RRVKREKRDE GYEAAASSKA SSGDASSLSI 120
EETNKLRAKL GLKPLEVNAV KKEAGTKEEP VAADVINPMA LRQREELREK LAAAKEKRLL 180
NQKLGKIKTL GEDDPWLDDT AAWIERSRQL QKEKDLAEKR AKLLEEMDQE FGVSTLVEEE 240
FEQRRQDLYS ARDLQGLTVE HAIDSFREGE TVVLTLKDKG VLQEGEDVLV NVNMVDKERA 300
DKNVELRKKK PDYLPYAEDE SVDDLAQQKP RSILAKYDEE LEGERPHSFR LEQGGMADGL 360
RERELEEIRT KLRLQAQSLN TVGPRLASEY LSPEEMVTFK KTKRRVKKIR KKEKEVIMRA 420
DDLLPLGEDQ TQDGDFGSRL RGRGRRRVPE VEEEALEDEE KDPVAQPPPS DDTRVENMDI 480
SDEEDGGALP SGPPELEEDE AELELQKQLE KGRRLRQLQQ LQQLRDSGEK VLEIVKKLES 540
RQRGWEEEED PERKGTIVFN ATSEFCRTLG EIPTYGLAGN REEQEELMDF ERDEERSANG 600
GSESDGEENI GWSTVNLDEE KQHQDFSASS TTILDEEPIV NRGLAAALLL CQNKGLLETT 660
VQKVARVKAP NKSLPSAVYC IEDKMAIDDK YSRREEYRGF TQDFKEKDGY KPDVKIEYVD 720
ETGRKLTPKE AFRQLSHRFH GKGSGKMKTE RRMKKLDEEA LLKKMSSSDT PLGTVALLQE 780
KQKAQKTPYI VLSGSGKSMN ANTITK 806 |
Gene Ontology | GO:0015030; C:Cajal body; IEA:Compara. GO:0071013; C:catalytic step 2 spliceosome; IEA:Compara. GO:0005794; C:Golgi apparatus; IEA:Compara. GO:0006397; P:mRNA processing; IEA:UniProtKB-KW. GO:0045585; P:positive regulation of cytotoxic T cell differentiation; IEA:Compara. GO:0008380; P:RNA splicing; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |