UniProt Accession

 UNC50_HUMAN; Q53HI1; D3DVH4; Q53S98; Q53TD6; Q5U5U2; Q6X7B9; Q9UQF4; Q9Y4S6 

Genbank Protein ID

 AY017215; AF077038; AL080115; AY251534; CR533464; AK222599; AC010134; AC064860; CH471127; CH471127; CH471127; BC017019; BC025992; BC039078; BC091481 

Genbank Nucleotide ID

 AAK08987.1; AAD27771.1; CAB45714.1; AAP20057.1; CAG38495.1; BAD96319.1; AAX93232.1; AAY14975.1; EAX01900.1; EAX01901.1; EAX01902.1; AAH17019.1; AAH25992.1; AAH39078.1; AAH91481.1 

Protein Name

 Protein unc-50 homolog 

Protein Synonyms/Alias

 Periodontal ligament-specific protein 22; PDLs22; Protein GMH1 homolog; hGMH1; Uncoordinated-like protein 

Gene Name

 UNC50 

Gene Synonyms/Alias

 UNCL; HSD-23; HSD23 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
74	FHYRKQTKDQWARDD	ubiquitination	[1, 2]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 May be involved in cell surface expression of neuronal nicotinic receptors. Binds RNA (By similarity). 

Sequence Annotation

  

Keyword

 Complete proteome; Golgi apparatus; Membrane; Nucleus; Protein transport; Reference proteome; RNA-binding; Transmembrane; Transmembrane helix; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 259 AA 

Protein Sequence

Gene Ontology

 GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005637; C:nuclear inner membrane; IEA:UniProtKB-SubCell.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
 GO:0007166; P:cell surface receptor signaling pathway; IEA:Compara.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW. 

Interpro

 IPR007881; UNC-50. 

Pfam

 PF05216; UNC-50 

SMART

  

PROSITE

  

PRINTS