UniProt Accession

 C9J809_HUMAN; C9J809 

Genbank Protein ID

 AC079775; AC138655 

Genbank Nucleotide ID

  

Protein Name

 DNA mismatch repair protein Msh2 

Protein Synonyms/Alias

  

Gene Name

 MSH2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
47	RAGNKASKENDWYLA	acetylation	[1]

Reference

 [1] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 140 AA 

Protein Sequence

Gene Ontology

 GO:0032301; C:MutSalpha complex; IEA:Compara.
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0016887; F:ATPase activity; IEA:Compara.
 GO:0019237; F:centromeric DNA binding; IEA:Compara.
 GO:0003684; F:damaged DNA binding; IEA:Compara.
 GO:0032137; F:guanine/thymine mispair binding; IEA:Compara.
 GO:0006915; P:apoptotic process; IEA:Compara.
 GO:0006200; P:ATP catabolic process; IEA:GOC.
 GO:0030183; P:B cell differentiation; IEA:Compara.
 GO:0007050; P:cell cycle arrest; IEA:Compara.
 GO:0008340; P:determination of adult lifespan; IEA:Compara.
 GO:0006302; P:double-strand break repair; IEA:Compara.
 GO:0007281; P:germ cell development; IEA:Compara.
 GO:0001701; P:in utero embryonic development; IEA:Compara.
 GO:0031573; P:intra-S DNA damage checkpoint; IEA:Compara.
 GO:0045190; P:isotype switching; IEA:Compara.
 GO:0008584; P:male gonad development; IEA:Compara.
 GO:0006298; P:mismatch repair; IEA:Compara.
 GO:0045910; P:negative regulation of DNA recombination; IEA:Compara.
 GO:0043524; P:negative regulation of neuron apoptotic process; IEA:Compara.
 GO:0006119; P:oxidative phosphorylation; IEA:Compara.
 GO:0010224; P:response to UV-B; IEA:Compara.
 GO:0010165; P:response to X-ray; IEA:Compara.
 GO:0016446; P:somatic hypermutation of immunoglobulin genes; IEA:Compara. 

Interpro

 IPR007695; DNA_mismatch_repair_MutS-lik_N.
 IPR007860; DNA_mmatch_repair_MutS_con_dom. 

Pfam

 PF01624; MutS_I
 PF05188; MutS_II 

SMART

  

PROSITE

  

PRINTS