UniProt Accession

 DESM_MOUSE; P31001 

Genbank Protein ID

 L22550; BC031760; Z18892 

Genbank Nucleotide ID

 AAH31760.1; CAA79330.1 

Protein Name

 Desmin 

Protein Synonyms/Alias

  

Gene Name

 Des 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
43	PRAGFGTKGSSSSMT	ubiquitination	[1]
108	LATRTNEKVELQELN	ubiquitination	[1]
124	RFANYIEKVRFLEQQ	ubiquitination	[1]
192	DLQRLKAKLQEEIQL	ubiquitination	[1]
240	EEIAFLKKVHEEEIR	ubiquitination	[1]
286	QYETIAAKNISEAEE	ubiquitination	[1]
296	SEAEEWYKSKVSDLT	ubiquitination	[1]
308	DLTQAANKNNDALRQ	ubiquitination	[1]
317	NDALRQAKQEMMEYR	ubiquitination	[1]
338	TCEIDALKGTNDSLM	ubiquitination	[1]
448	TKKTVMIKTIETRDG	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Desmin are class-III intermediate filaments found in muscle cells. In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures. 

Sequence Annotation

 REGION 1 108 Head.
 REGION 109 411 Rod.
 REGION 109 140 Coil 1A.
 REGION 141 150 Linker 1.
 REGION 151 251 Coil 1B.
 REGION 252 267 Linker 12.
 REGION 268 286 Coil 2A.
 REGION 287 294 Linker 2.
 REGION 295 411 Coil 2B.
 REGION 412 469 Tail.
 MOD_RES 12 12 Phosphoserine; by AURKB (By similarity).
 MOD_RES 17 17 Phosphothreonine; by AURKB (By
 MOD_RES 58 58 ADP-ribosylarginine (By similarity).
 MOD_RES 60 60 Phosphoserine; by AURKB (By similarity).  

Keyword

 ADP-ribosylation; Coiled coil; Complete proteome; Cytoplasm; Intermediate filament; Muscle protein; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 469 AA 

Protein Sequence

Gene Ontology

 GO:0005856; C:cytoskeleton; IDA:MGI.
 GO:0005916; C:fascia adherens; IDA:MGI.
 GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
 GO:0031594; C:neuromuscular junction; IDA:MGI.
 GO:0042383; C:sarcolemma; IDA:MGI.
 GO:0030018; C:Z disc; IDA:MGI.
 GO:0005200; F:structural constituent of cytoskeleton; TAS:MGI.
 GO:0007517; P:muscle organ development; TAS:MGI. 

Interpro

 IPR016044; F.
 IPR001664; IF.
 IPR006821; Intermed_filament_DNA-bd.
 IPR018039; Intermediate_filament_CS. 

Pfam

 PF00038; Filament
 PF04732; Filament_head 

SMART

  

PROSITE

 PS00226; IF 

PRINTS