UniProt Accession

 GET4_HUMAN; Q7L5D6; A4D2Q1; B3KNC7; Q9UFC9; Q9Y309 

Genbank Protein ID

 AK024305; AK097899; AK125863; AL133014; CH236965; BC003550; AF132954 

Genbank Nucleotide ID

 BAG51289.1; BAG53546.1; BAG54258.1; CAB61355.1; EAL23708.1; AAH03550.2; AAD27729.1 

Protein Name

 Golgi to ER traffic protein 4 homolog 

Protein Synonyms/Alias

 Conserved edge-expressed protein; Transmembrane domain recognition complex 35 kDa subunit; TRC35 

Gene Name

 GET4 

Gene Synonyms/Alias

 C7orf20; CEE; TRC35; CGI-20 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
36	KLRASVEKGDYYEAH	acetylation	[1, 2]
36	KLRASVEKGDYYEAH	ubiquitination	[3]
131	TFVSRALKWSSGGSG	ubiquitination	[3]
139	WSSGGSGKLGHPRLH	ubiquitination	[3]

Reference

 [1] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Component of the BAT3 complex, a multiprotein complex involved in the post-translational delivery of tail-anchored (TA) membrane proteins to the endoplasmic reticulum membrane. TA membrane proteins, also named type II transmembrane proteins, contain a single C-terminal transmembrane region. The complex acts by facilitating TA proteins capture by ASNA1/TRC40: it is recruited to ribosomes synthesizing membrane proteins, interacts with the transmembrane region of newly released TA proteins, and transfers them to ASNA1/TRC40 for targeting. 

Sequence Annotation

 MOD_RES 2 2 N-acetylalanine.  

Keyword

 Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 327 AA 

Protein Sequence

Gene Ontology

 GO:0071818; C:BAT3 complex; IDA:UniProtKB.
 GO:0071816; P:tail-anchored membrane protein insertion into ER membrane; IMP:UniProtKB.
 GO:0006810; P:transport; IEA:UniProtKB-KW. 

Interpro

 IPR007317; UPF0363. 

Pfam

 PF04190; DUF410 

SMART

  

PROSITE

  

PRINTS