UniProt Accession

 UCRIL_HUMAN; P0C7P4 

Genbank Protein ID

 Z82206; CR592425 

Genbank Nucleotide ID

  

Protein Name

 Putative cytochrome b-c1 complex subunit Rieske-like protein 1 

Protein Synonyms/Alias

 Ubiquinol-cytochrome c reductase Rieske iron-sulfur subunit pseudogene 1 

Gene Name

 UQCRFS1P1 

Gene Synonyms/Alias

 UQCRFSL1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
55	EQPVLDLKRPFLSRE	ubiquitination	[1]
110	LEVLDSTKSSRESTE	ubiquitination	[1]
164	ALAKIEIKLSDIPEG	ubiquitination	[1]
172	LSDIPEGKNMAFKWR	ubiquitination	[1, 2, 3]
177	EGKNMAFKWRGKPLF	ubiquitination	[2]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

  

Sequence Annotation

 DOMAIN 196 281 Rieske.
 METAL 226 226 Iron-sulfur (2Fe-2S) (By similarity).
 METAL 228 228 Iron-sulfur (2Fe-2S); via pros nitrogen
 METAL 245 245 Iron-sulfur (2Fe-2S) (By similarity).
 METAL 248 248 Iron-sulfur (2Fe-2S); via pros nitrogen
 DISULFID 231 247 By similarity.  

Keyword

 2Fe-2S; Complete proteome; Disulfide bond; Iron; Iron-sulfur; Metal-binding; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 283 AA 

Protein Sequence

Gene Ontology

 GO:0016020; C:membrane; IEA:InterPro.
 GO:0005739; C:mitochondrion; IDA:HPA.
 GO:0051537; F:2 iron, 2 sulfur cluster binding; IEA:UniProtKB-KW.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0008121; F:ubiquinol-cytochrome-c reductase activity; IEA:InterPro. 

Interpro

 IPR011070; Globular_prot_asu/bsu.
 IPR017941; Rieske_2Fe-2S.
 IPR014349; Rieske_Fe-S_prot.
 IPR005805; Rieske_Fe-S_prot_C.
 IPR015248; Ubiqinol_cyt_c_Rdtase_N.
 IPR006317; Ubiquinol_cyt_c_Rdtase_Fe-S-su.
 IPR004192; Ubiquinol_cyt_Rdtase_TM. 

Pfam

 PF00355; Rieske
 PF09165; Ubiq-Cytc-red_N
 PF02921; UCR_TM 

SMART

  

PROSITE

 PS51296; RIESKE 

PRINTS

 PR00162; RIESKE.