CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021845
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 MAGUK p55 subfamily member 5 
Protein Synonyms/Alias
 Protein associated with Lin-7 1 
Gene Name
 Mpp5 
Gene Synonyms/Alias
 Pals1 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
544EADIAAGKFIEHGEFubiquitination[1]
553IEHGEFEKNLYGTSIubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 May play a role in tight junctions biogenesis and in the establishment of cell polarity in epithelial cells. May modulate SC6A1/GAT1-mediated GABA uptake by stabilizing the transporter. Required for localization of EZR to the apical membrane of parietal cells and may play a role in the dynamic remodeling of the apical cytoskeleton. 
Sequence Annotation
 DOMAIN 120 177 L27 1.
 DOMAIN 179 235 L27 2.
 DOMAIN 256 336 PDZ.
 DOMAIN 345 417 SH3.
 DOMAIN 479 660 Guanylate kinase-like.
 REGION 21 140 Interaction with PARD6B.
 REGION 181 243 Interaction with LIN7C.
 MOD_RES 25 25 Phosphoserine (By similarity).  
Keyword
 3D-structure; Cell junction; Cell membrane; Complete proteome; Membrane; Phosphoprotein; Reference proteome; Repeat; SH3 domain; Tight junction. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 675 AA 
Protein Sequence
MTTSYMNGHV TEESDSGIKN LDLASPEEYP KHREMAVDCP GDLGTRMMPV RRSAQLERIR 60
QQQEDMRRRR EEEGKKQELD LNSSMRLKKL AQIPPKTGID NPIFDTEEGI VLESPHYAVN 120
ILDVEDLFSS LKHIQHTLVD SQSQEDISLL LQLVQNRDFQ NAFKIHNAVT VHMSKASPPF 180
PLIANVQDLV QEVQTVLKPV HQKEGQELTA LLNAPHIQAL LLAHDKVAEQ EMQLEPITDE 240
RVYESIGHYG GETVKIVRIE KARDIPLGAT VRNEMDSVII SRIVKGGAAE KSGLLHEGDE 300
VLEINGIEIR GKDVNEVFDL LSDMHGTLTF VLIPSQQIKP PPAKETVIHV KAHFDYDPSD 360
DPYVPCRELG LSFQKGDILH VISQEDPNWW QAYREGDEDN QPLAGLVPGK SFQQQREAMK 420
QTIEEDKEPE KSGKLWCAKK NKKKRKKVLY NANKNDDYDN EEILTYEEMS LYHQPANRKR 480
PIILIGPQNC GQNELRQRLM NKEKDRFASA VPHTTRNRRD HEVAGRDYHF VSRQAFEADI 540
AAGKFIEHGE FEKNLYGTSI DSVRQVINSG KICLLSLRTQ SLKTLRNSDL KPYIIFIAPP 600
SQERLRALLA KEGKNPKPEE LREIIEKTRE MEQNNGHYFD TAIVNSDLDK AYQELLRLIN 660
KLDTEPQWVP STWLR 675 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; ISS:MGI.
 GO:0043219; C:lateral loop; IDA:BHF-UCL.
 GO:0035749; C:myelin sheath adaxonal region; IDA:BHF-UCL.
 GO:0005886; C:plasma membrane; IDA:MGI.
 GO:0043234; C:protein complex; IEA:Compara.
 GO:0043220; C:Schmidt-Lanterman incisure; IDA:BHF-UCL.
 GO:0005923; C:tight junction; IEA:UniProtKB-SubCell.
 GO:0004385; F:guanylate kinase activity; ISS:MGI.
 GO:0090002; P:establishment of protein localization to plasma membrane; IEA:Compara.
 GO:0032288; P:myelin assembly; IEA:Compara.
 GO:0032287; P:peripheral nervous system myelin maintenance; IMP:BHF-UCL.
 GO:0035750; P:protein localization to myelin sheath abaxonal region; IMP:BHF-UCL. 
Interpro
 IPR008144; Guanylate_kin.
 IPR008145; Guanylate_kin/L-typ_Ca_channel.
 IPR020590; Guanylate_kinase_CS.
 IPR004172; L27.
 IPR014775; L27_C.
 IPR015145; L27_N.
 IPR027417; P-loop_NTPase.
 IPR001478; PDZ.
 IPR011511; SH3_2.
 IPR001452; SH3_domain. 
Pfam
 PF00625; Guanylate_kin
 PF02828; L27
 PF09060; L27_N
 PF00595; PDZ
 PF07653; SH3_2 
SMART
 SM00072; GuKc
 SM00569; L27
 SM00228; PDZ
 SM00326; SH3 
PROSITE
 PS00856; GUANYLATE_KINASE_1
 PS50052; GUANYLATE_KINASE_2
 PS51022; L27
 PS50106; PDZ
 PS50002; SH3 
PRINTS