| Tag | Content |
|---|
| CPLM ID | CPLM-013853 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Regulator of telomere elongation helicase 1 |
Protein Synonyms/Alias | |
Gene Name | Rtel1 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 1179 | KPEKTQSKISSFLRQ | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | ATP-dependent DNA helicase required to suppress inappropriate homologous recombination, thereby playing a central role DNA repair and in the maintenance of genomic stability. Antagonizes homologous recombination by promoting the disassembly of D loop recombination intermediates. Also required to regulate telomere length; probably due to its anti-recombinase function (By similarity). |
Sequence Annotation | DOMAIN 7 296 Helicase ATP-binding.
NP_BIND 42 49 ATP (By similarity).
MOTIF 151 167 Nuclear localization signal (Potential).
MOTIF 250 253 DEAH box.
MOTIF 871 877 Nuclear localization signal (Potential).
METAL 145 145 Iron-sulfur (4Fe-4S) (By similarity).
METAL 163 163 Iron-sulfur (4Fe-4S) (By similarity).
METAL 172 172 Iron-sulfur (4Fe-4S) (By similarity).
METAL 207 207 Iron-sulfur (4Fe-4S) (By similarity). |
Keyword | 4Fe-4S; Alternative splicing; ATP-binding; Complete proteome; DNA damage; DNA repair; DNA-binding; Helicase; Hydrolase; Iron; Iron-sulfur; Metal-binding; Nucleotide-binding; Nucleus; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1274 AA |
Protein Sequence | MPRVVLNGVT VDFPFQPYPC QQEYMTKVLE CLQKKVNGIL ESPTGTGKTL CLLCTTLAWR 60
EHLRDAVSSL KIAERVQGEL FASRTLSSWR SAADANGDSI DCYTDIPKII YASRTHSQLT 120
QVIGELRNTS YRPKVCVLGS REQLCIHPEV KKQESNHMQI SLCRKKVASR SCHFYNNVEE 180
KSLEQELATP ILDIEDLVKN GSKHKVCPYY LSRNLKQQAD IIFMPYNYLL DAKSRKAHNI 240
DLKGTVVIFD EAHNVEKICE ESASFDLTPR DVASGLEVIN QVLEEQARVA QHGELQQEFI 300
IDTSSSGLNM ELEDIAKLKM ILLHLEEAID AVQLPGDDRG VTKPGSYIFE LFAEAQITFQ 360
TKGCILESLD QIIQHLTGRT GVFTNTAGLQ KLMDIIQIVF SVDPLEGSPG SQVGLGSSHF 420
YKVHIHPETS HRRAAQRSDA WSTTASRKQG KVLSYWCFSP SHSMRELVQQ GVRTLILTSG 480
TLAPLSSFAL EMQIPFPVCL ENPHIIDKNQ LWVGVIPRGP DGVQLSSAYD KRFSEECLSS 540
LGKALGNIAR VVPHGLLVFF PSYPVMEKSL EFWQAQGMSK KVEALKPLFV EPRNKGSFSE 600
VIDAYYQQVA SPGSNGATFL AVCRGKASEG LDFSDMNGRG VIVTGLPYPP RMDPRVILKM 660
QFLDEMKGRS RVGGQCLSGQ EWYQQQASRA VNQAIGRVIR HRHDYGAIFL CDHRFAYADA 720
RAHLPSWVRP YLKVYDNFGR VIRDVAQFFR VAQKAMPLPV PQAVTSSVSE GEAAVKEATL 780
SSHSLSTRKA MSLDVHVPSL RRRPVGLPTA GDSESSVCVE YEQQTFSAQK RPMGLLAALE 840
YNEQKAGASE EQALSSSTPS LRCEKRLSVE QRGGKKKVRL VNHPEEPVAG TQAGRAKMFM 900
VAVKQALSQA NFDTFTQALQ HYKSSDDFEA LVASLTCLFA EDPKKHTLLK GFYQFVRPHH 960
KQQFEDICFQ LTGQRCSYQP GNSLPFGEQA QSTASKQGRR ELESKLTLSE GADRQLDPGE 1020
HLNQGWPHLS THLTSKGDTS NCPKVGCVGE KPGQPAVNDY LSDVHKALGS ASCNQLTAAL 1080
RAYKQDDDLD KVLAVVAALT TAKPEHLSLL QRFGMFIRRH HKPRFVQTCA DLMGLPTIGK 1140
GLELPCPRDE STTVPSELTH EDMKPGPSTS KKPEKTQSKI SSFLRQRPDQ SARSDDTIMQ 1200
LPPRLPPEHT TSQWNFVCPA CATEDTVLFQ CPSCDFCRCR ACWQRQLQAS RLCPACGAVN 1260
RKQSIAQVIW PKPQ 1274 |
Gene Ontology | GO:0005634; C:nucleus; ISS:UniProtKB. GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW. GO:0005524; F:ATP binding; ISS:UniProtKB. GO:0004003; F:ATP-dependent DNA helicase activity; ISS:UniProtKB. GO:0003677; F:DNA binding; IEA:UniProtKB-KW. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0006281; P:DNA repair; IEA:UniProtKB-KW. GO:0010569; P:regulation of double-strand break repair via homologous recombination; ISS:UniProtKB. GO:0000723; P:telomere maintenance; ISS:UniProtKB. |
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