| Tag | Content |
|---|
| CPLM ID | CPLM-013821 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Thioredoxin-interacting protein |
Protein Synonyms/Alias | |
Gene Name | TXNIP |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) |
NCBI Taxa ID | 9601 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 19 | VVFNDPEKVYGSGEK | ubiquitination | [1] | | 26 | KVYGSGEKVAGRVIV | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1) (By similarity). Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth (By similarity). |
Sequence Annotation | MOD_RES 361 361 Phosphoserine (By similarity).
CROSSLNK 212 212 Glycyl lysine isopeptide (Lys-Gly) |
Keyword | Cell cycle; Complete proteome; Cytoplasm; Isopeptide bond; Phosphoprotein; Reference proteome; Transcription; Transcription regulation; Tumor suppressor; Ubl conjugation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 391 AA |
Protein Sequence | MVMFKKIKSF EVVFNDPEKV YGSGEKVAGR VIVEVCEVTR VKAVRILACG VAKVLWMQGS 60
QQCKQTSEYL RYEDTLLLED QPTGENEMVI MRPGNKYEYK FGFELPQGPL GTSFKGKYGC 120
VDYWVKAFLD RPSQPTQGTK KNFEVVDLVD VNTPDLMAPV SAKKEKKVSC MFIPDGRVSV 180
SARIDRKGFC EGDEISIHAD FENTCSRIVV PKAAIVARHT YLANGQTKVL TQELSSVRGN 240
HIISGTCASW RGKSLRVQKI RPSILGCNIL RVEYSLLIYV SVPGSKKVIL DLPLVIGSRS 300
GLSSRTSSMA SRTSSEMSWV DLNIPDTPEA PPCYMDIIPE DHRLESPTTP LLDDMDGSQD 360
SPIFMYAPEF KFMPPPTYTE VDPCILNNNV Q 391 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0007049; P:cell cycle; IEA:UniProtKB-KW. GO:0071228; P:cellular response to tumor cell; ISS:UniProtKB. GO:0051782; P:negative regulation of cell division; ISS:UniProtKB. GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |