UniProt Accession

 NDUB9_HUMAN; Q9Y6M9; B2R8M6; Q9UQE8 

Genbank Protein ID

 AF044956; AF261090; AF067168; AK313432; CH471060; BC007672 

Genbank Nucleotide ID

 AAD42057.1; AAF99683.1; AAD32452.1; BAG36223.1; EAW92068.1; AAH07672.1 

Protein Name

 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 

Protein Synonyms/Alias

 Complex I-B22; CI-B22; LYR motif-containing protein 3; NADH-ubiquinone oxidoreductase B22 subunit 

Gene Name

 NDUFB9 

Gene Synonyms/Alias

 LYRM3; UQOR22 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
15	PYLTHQQKVLRLYKR	ubiquitination	[1, 2, 3]
59	KNEKDMAKATQLLKE	ubiquitination	[4]
65	AKATQLLKEAEEEFW	ubiquitination	[4, 5]
121	MYPDYFAKREQWKKL	ubiquitination	[4, 5]
138	ESWEREVKQLQEETP	ubiquitination	[4, 5]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [4] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [5] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. 

Sequence Annotation

 MOD_RES 2 2 N-acetylalanine.
 MOD_RES 85 85 Phosphoserine.  

Keyword

 Acetylation; Complete proteome; Direct protein sequencing; Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane; Phosphoprotein; Polymorphism; Reference proteome; Respiratory chain; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 179 AA 

Protein Sequence

Gene Ontology

 GO:0005747; C:mitochondrial respiratory chain complex I; IDA:UniProtKB.
 GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; NAS:UniProtKB.
 GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; NAS:UniProtKB.
 GO:0007605; P:sensory perception of sound; TAS:ProtInc.
 GO:0044281; P:small molecule metabolic process; TAS:Reactome. 

Interpro

 IPR008011; Complex1_LYR. 

Pfam

 PF05347; Complex1_LYR 

SMART

  

PROSITE

  

PRINTS