CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-010230
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Transcriptional regulator LsrR 
Protein Synonyms/Alias
  
Gene Name
 lsrR 
Gene Synonyms/Alias
 ydeW; b1512; JW1505 
Created Date
 July 27, 2013 
Organism
 Escherichia coli (strain K12) 
NCBI Taxa ID
 83333 
Lysine Modification
Position
Peptide
Type
References
53KVSRLLEKGHQSGIIacetylation[1]
Reference
 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 
Functional Description
 Regulates transcription of many different genes. In the absence of autoinducer 2 (AI-2), represses transcription of the lsrACDBFG operon and its own transcription. In the presence of AI- 2, LsrR is inactivated by binding phospho-AI-2, leading to the transcription of the lsr genes. 
Sequence Annotation
 DNA_BIND 33 52 H-T-H motif (Potential).  
Keyword
 3D-structure; Activator; Complete proteome; Cytoplasm; DNA-binding; Reference proteome; Repressor; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 317 AA 
Protein Sequence
MTINDSAISE QGMCEEEQVA RIAWFYYHDG LTQSEISDRL GLTRLKVSRL LEKGHQSGII 60
RVQINSRFEG CLEYETQLRR QFSLQHVRVI PGLADADVGG RLGIGAAHML MSLLQPQQML 120
AIGFGEATMN TLQRLSGFIS SQQIRLVTLS GGVGSYMTGI GQLNAACSVN IIPAPLRASS 180
ADIARTLKNE NCVKDVLLAA QAADVAIVGI GAVSQQDDAT IIRSGYISQG EQLMIGRKGA 240
VGDILGYFFD AKGDVVTNIK IHNELIGLPL SALKTIPVRV GVAGGENKAE AIAAAMKGGY 300
INALVTDQDT AAAILRS 317 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0030246; F:carbohydrate binding; IEA:InterPro.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEP:EcoCyc. 
Interpro
 IPR007324; Sugar-bd_dom_put.
 IPR011991; WHTH_DNA-bd_dom. 
Pfam
 PF04198; Sugar-bind 
SMART
  
PROSITE
  
PRINTS