| Tag | Content |
|---|
| CPLM ID | CPLM-006477 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Nuclear receptor ROR-alpha |
Protein Synonyms/Alias | Nuclear receptor RZR-alpha; Nuclear receptor subfamily 1 group F member 1; Retinoid-related orphan receptor-alpha |
Gene Name | RORA |
Gene Synonyms/Alias | NR1F1; RZRA |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 273 | GLDINGIKPEPICDY | sumoylation | [1] |
|
Reference | [1] SUMOylation of RORalpha potentiates transcriptional activation function. Hwang EJ, Lee JM, Jeong J, Park JH, Yang Y, Lim JS, Kim JH, Baek SH, Kim KI. Biochem Biophys Res Commun. 2009 Jan 16;378(3):513-7. [ PMID: 19041634] |
Functional Description | Orphan nuclear receptor. Binds DNA as a monomer to hormone response elements (HRE) containing a single core motif half-site preceded by a short A-T-rich sequence. This isomer binds to the consensus sequence 5'-[AT][TA]A[AT][CGT]TAGGTCA-3'. Regulates a number of genes involved in lipid metabolism such as apolipoproteins AI, APOA5, CIII, CYP71 and PPARgamma, in cerebellum and photoreceptor development including PCP2, OPN1SW, OPN1SM AND ARR3, in circadian rhythm with BMAL1, and skeletal muscle development with MYOD1. Possible receptor for cholesterol or one of its derivatives. |
Sequence Annotation | DNA_BIND 106 171 Nuclear receptor.
ZN_FING 106 126 NR C4-type.
ZN_FING 142 166 NR C4-type.
REGION 1 105 Modulating.
REGION 172 304 Hinge.
REGION 305 556 Ligand-binding.
CROSSLNK 273 273 Glycyl lysine isopeptide (Lys-Gly) |
Keyword | 3D-structure; Activator; Alternative splicing; Complete proteome; DNA-binding; Isopeptide bond; Metal-binding; Nucleus; Phosphoprotein; Polymorphism; Receptor; Reference proteome; Transcription; Transcription regulation; Ubl conjugation; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 556 AA |
Protein Sequence | MNEGAPGDSD LETEARVPWS IMGHCLRTGQ ARMSATPTPA GEGARRDELF GILQILHQCI 60
LSSGDAFVLT GVCCSWRQNG KPPYSQKEDK EVQTGYMNAQ IEIIPCKICG DKSSGIHYGV 120
ITCEGCKGFF RRSQQSNATY SCPRQKNCLI DRTSRNRCQH CRLQKCLAVG MSRDAVKFGR 180
MSKKQRDSLY AEVQKHRMQQ QQRDHQQQPG EAEPLTPTYN ISANGLTELH DDLSNYIDGH 240
TPEGSKADSA VSSFYLDIQP SPDQSGLDIN GIKPEPICDY TPASGFFPYC SFTNGETSPT 300
VSMAELEHLA QNISKSHLET CQYLREELQQ ITWQTFLQEE IENYQNKQRE VMWQLCAIKI 360
TEAIQYVVEF AKRIDGFMEL CQNDQIVLLK AGSLEVVFIR MCRAFDSQNN TVYFDGKYAS 420
PDVFKSLGCE DFISFVFEFG KSLCSMHLTE DEIALFSAFV LMSADRSWLQ EKVKIEKLQQ 480
KIQLALQHVL QKNHREDGIL TKLICKVSTL RALCGRHTEK LMAFKAIYPD IVRLHFPPLY 540
KELFTSEFEP AMQIDG 556 |
Gene Ontology | GO:0005654; C:nucleoplasm; TAS:Reactome. GO:0004879; F:ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; TAS:ProtInc. GO:0043565; F:sequence-specific DNA binding; IEA:InterPro. GO:0003707; F:steroid hormone receptor activity; IEA:InterPro. GO:0008270; F:zinc ion binding; IEA:InterPro. GO:0021702; P:cerebellar Purkinje cell differentiation; IEA:Compara. GO:0046068; P:cGMP metabolic process; IEA:Compara. GO:0006809; P:nitric oxide biosynthetic process; IEA:Compara. GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:MGI. GO:0043030; P:regulation of macrophage activation; IEA:Compara. GO:0006367; P:transcription initiation from RNA polymerase II promoter; TAS:Reactome. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |