CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-001521
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 G2/mitotic-specific cyclin-B2 
Protein Synonyms/Alias
  
Gene Name
 CCNB2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
25TGVNSKVKSHVTIRRubiquitination[1]
64KVPVQPTKTTNVNKQubiquitination[1]
79LKPTASVKPVQMEKLubiquitination[1]
275HFLRRASKAGEVDVEubiquitination[1, 2]
318AASCLSQKVLGQGKWubiquitination[1]
324QKVLGQGKWNLKQQYubiquitination[1]
328GQGKWNLKQQYYTGYubiquitination[1]
360KVNENLTKFIAIKNKubiquitination[3, 4]
388QLNSKAVKDLASPLIubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
 Essential for the control of the cell cycle at the G2/M (mitosis) transition. 
Sequence Annotation
 MOD_RES 92 92 Phosphoserine.
 MOD_RES 94 94 Phosphothreonine.
 MOD_RES 99 99 Phosphoserine.
 MOD_RES 392 392 Phosphoserine.
 MOD_RES 398 398 Phosphoserine.  
Keyword
 Cell cycle; Cell division; Complete proteome; Cyclin; Mitosis; Phosphoprotein; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 398 AA 
Protein Sequence
MALLRRPTVS SDLENIDTGV NSKVKSHVTI RRTVLEEIGN RVTTRAAQVA KKAQNTKVPV 60
QPTKTTNVNK QLKPTASVKP VQMEKLAPKG PSPTPEDVSM KEENLCQAFS DALLCKIEDI 120
DNEDWENPQL CSDYVKDIYQ YLRQLEVLQS INPHFLDGRD INGRMRAILV DWLVQVHSKF 180
RLLQETLYMC VGIMDRFLQV QPVSRKKLQL VGITALLLAS KYEEMFSPNI EDFVYITDNA 240
YTSSQIREME TLILKELKFE LGRPLPLHFL RRASKAGEVD VEQHTLAKYL MELTLIDYDM 300
VHYHPSKVAA AASCLSQKVL GQGKWNLKQQ YYTGYTENEV LEVMQHMAKN VVKVNENLTK 360
FIAIKNKYAS SKLLKISMIP QLNSKAVKDL ASPLIGRS 398 
Gene Ontology
 GO:0005813; C:centrosome; IDA:UniProtKB.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0016020; C:membrane; IEA:Compara.
 GO:0005634; C:nucleus; IEA:InterPro.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0000086; P:G2/M transition of mitotic cell cycle; TAS:Reactome.
 GO:0040007; P:growth; IEA:Compara.
 GO:0001701; P:in utero embryonic development; IEA:Compara.
 GO:0007067; P:mitosis; IEA:UniProtKB-KW.
 GO:0007077; P:mitotic nuclear envelope disassembly; TAS:Reactome.
 GO:0000079; P:regulation of cyclin-dependent protein serine/threonine kinase activity; IEA:InterPro.
 GO:0043029; P:T cell homeostasis; IEA:Compara.
 GO:0048538; P:thymus development; IEA:Compara. 
Interpro
 IPR013763; Cyclin-like.
 IPR014400; Cyclin_A/B/D/E.
 IPR004367; Cyclin_C-dom.
 IPR006671; Cyclin_N. 
Pfam
 PF02984; Cyclin_C
 PF00134; Cyclin_N 
SMART
 SM00385; CYCLIN 
PROSITE
 PS00292; CYCLINS 
PRINTS