UniProt Accession

 KTNB1_MOUSE; Q8BG40; Q8CD18; Q8R1J0; Q9CWV2 

Genbank Protein ID

 AK010364; AK031630; AK034103; AK049345; AK087973; BC024500; BC045200 

Genbank Nucleotide ID

 BAB26884.1; BAC27487.1; BAC28588.1; BAC33697.1; BAC40067.1; AAH24500.1; AAH45200.1 

Protein Name

 Katanin p80 WD40 repeat-containing subunit B1 

Protein Synonyms/Alias

 Katanin p80 subunit B1; p80 katanin 

Gene Name

 Katnb1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
96	VWDLEAAKILRTLMG	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth (By similarity). 

Sequence Annotation

 REPEAT 18 58 WD 1.
 REPEAT 61 100 WD 2.
 REPEAT 103 142 WD 3.
 REPEAT 145 184 WD 4.
 REPEAT 187 226 WD 5.
 REPEAT 229 269 WD 6.
 REGION 1 300 Interaction with centrosomes (By
 REGION 1 284 Interaction with dynein.
 REGION 285 437 Interaction with PAFAH1B1.
 REGION 436 658 Interaction with KATNA1 and NDEL1.  

Keyword

 Cell cycle; Cell division; Complete proteome; Cytoplasm; Cytoskeleton; Microtubule; Mitosis; Reference proteome; Repeat; WD repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 658 AA 

Protein Sequence

Gene Ontology

 GO:0030424; C:axon; IDA:MGI.
 GO:0005813; C:centrosome; IDA:MGI.
 GO:0030426; C:growth cone; IEA:Compara.
 GO:0008352; C:katanin complex; IEA:InterPro.
 GO:0005874; C:microtubule; IEA:UniProtKB-KW.
 GO:0030496; C:midbody; IEA:Compara.
 GO:0043025; C:neuronal cell body; IEA:Compara.
 GO:0005886; C:plasma membrane; IEA:Compara.
 GO:0000922; C:spindle pole; IEA:UniProtKB-SubCell.
 GO:0045502; F:dynein binding; IDA:MGI.
 GO:0008568; F:microtubule-severing ATPase activity; IEA:Compara.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0051013; P:microtubule severing; IEA:Compara.
 GO:0007067; P:mitosis; IEA:UniProtKB-KW.
 GO:0007026; P:negative regulation of microtubule depolymerization; IEA:Compara.
 GO:0010942; P:positive regulation of cell death; IEA:Compara.
 GO:0031117; P:positive regulation of microtubule depolymerization; IEA:Compara.
 GO:0010976; P:positive regulation of neuron projection development; IEA:Compara. 

Interpro

 IPR020472; G-protein_beta_WD-40_rep.
 IPR026962; Katanin_bsu1.
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR019775; WD40_repeat_CS.
 IPR017986; WD40_repeat_dom. 

Pfam

 PF00400; WD40 

SMART

 SM00320; WD40 

PROSITE

 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 

PRINTS

 PR00320; GPROTEINBRPT.