CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013271
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Nuclear speckle splicing regulatory protein 1 
Protein Synonyms/Alias
 Coiled-coil domain-containing protein 55; Nuclear speckle-related protein 70; NSrp70 
Gene Name
 Nsrp1 
Gene Synonyms/Alias
 Ccdc55; Nsrp70 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
25PLNRVLQKPSVFGNDacetylation[1]
299EEGGLSTKYHSRSSQacetylation[1]
511RPPEAVSKFAKRSNEacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 RNA-binding protein that mediates pre-mRNA alternative splicing regulation (By similarity). 
Sequence Annotation
 REGION 105 169 Necessary for alternative splicing
 MOD_RES 27 27 Phosphoserine (By similarity).
 MOD_RES 33 33 Phosphoserine (By similarity).
 MOD_RES 247 247 Phosphoserine (By similarity).
 MOD_RES 252 252 Phosphoserine (By similarity).  
Keyword
 Coiled coil; Complete proteome; mRNA processing; mRNA splicing; Nucleus; Phosphoprotein; Reference proteome; RNA-binding. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 547 AA 
Protein Sequence
MAIPGRQYGL ILPKKTQPLN RVLQKPSVFG NDSDDDEASV SESLQREAAK KQAMRQTKLE 60
IQKALAEDST VYEYDSIYDE MQKKKEENNP KLLMGKDRKP KYIHNLLKAV EIRKKEQEKR 120
MEKKIQRERE MEKGEFDDKE AFVTSAYKKK LEERAEEEER EKRAAALEAR LDVTKQKDLS 180
GFYRHLLNQA VGEEAVPKSS FREARTVIKE EKLRGYPDET NSENRPQQNC ALQSGVEEAE 240
ENPDADSDSE ESCDDGERGD HKVKSRGEED TGASTKYLKH HKNHTHSRSS SEEGGLSTKY 300
HSRSSQSRGH EHKGGQHQDR QSRDQESCHK DRSHREEKSS HRHREASHKD HHWKRHEHED 360
KPKGRGQGER QDREWKREKY SSREQEKDRQ WNDHDRYSEK EKKGKEKEEH RKARRERCED 420
GAKYRERKKP EGSGQSSERH RDRRESSPRP RPEDDLLDQE RSSKARNTEK DKGEQGKPPR 480
SETSLATKHR LTEERPEKGS QPERPPEAVS KFAKRSNEET VMSARDRYLA RQMARINAKT 540
YIEKEDD 547 
Gene Ontology
 GO:0016607; C:nuclear speck; ISS:UniProtKB.
 GO:0030529; C:ribonucleoprotein complex; ISS:UniProtKB.
 GO:0003729; F:mRNA binding; ISS:UniProtKB.
 GO:0032502; P:developmental process; ISS:UniProtKB.
 GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
 GO:0006913; P:nucleocytoplasmic transport; ISS:UniProtKB.
 GO:0000381; P:regulation of alternative mRNA splicing, via spliceosome; ISS:UniProtKB.
 GO:0008380; P:RNA splicing; IEA:UniProtKB-KW. 
Interpro
 IPR018612; DUF2040. 
Pfam
 PF09745; DUF2040 
SMART
  
PROSITE
  
PRINTS