UniProt Accession

 TXD12_RAT; Q498E0 

Genbank Protein ID

 BC100255 

Genbank Nucleotide ID

 AAI00256.1 

Protein Name

 Thioredoxin domain-containing protein 12 

Protein Synonyms/Alias

  

Gene Name

 Txndc12 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
164	TGDAFREKHFQDEL*	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Possesses significant protein thiol-disulfide oxidase activity (By similarity). 

Sequence Annotation

 MOTIF 167 170 Prevents secretion from ER (Potential).
 CARBOHYD 128 128 N-linked (GlcNAc...) (Potential).
 DISULFID 64 67 Redox-active (Potential).  

Keyword

 Complete proteome; Disulfide bond; Endoplasmic reticulum; Glycoprotein; Oxidoreductase; Redox-active center; Reference proteome; Signal. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 170 AA 

Protein Sequence

Gene Ontology

 GO:0005788; C:endoplasmic reticulum lumen; IEA:UniProtKB-SubCell.
 GO:0019153; F:protein-disulfide reductase (glutathione) activity; IEA:EC.
 GO:0045454; P:cell redox homeostasis; IEA:InterPro. 

Interpro

 IPR012336; Thioredoxin-like_fold.
 IPR017937; Thioredoxin_CS. 

Pfam

  

SMART

  

PROSITE

 PS00014; ER_TARGET
 PS00194; THIOREDOXIN_1
 PS51352; THIOREDOXIN_2 

PRINTS