| Tag | Content |
|---|
| CPLM ID | CPLM-016373 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Negative elongation factor A |
Protein Synonyms/Alias | NELF-A; Wolf-Hirschhorn syndrome candidate 2 homolog; mWHSC2 |
Gene Name | Nelfa |
Gene Synonyms/Alias | Whsc2; Whsc2h |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 255 | LQKERGVKLLDISEL | acetylation | [1] |
|
Reference | [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways. Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y. Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [ PMID: 22826441] |
Functional Description | Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex. Probably required to interact with the RNA polymerase II complex (By similarity). |
Sequence Annotation | DOMAIN 189 248 HDAg-like.
MOD_RES 157 157 Phosphothreonine (By similarity).
MOD_RES 277 277 Phosphothreonine.
MOD_RES 363 363 Phosphoserine (By similarity). |
Keyword | Complete proteome; Nucleus; Phosphoprotein; Reference proteome; Repressor; Transcription; Transcription regulation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 530 AA |
Protein Sequence | MASMRESDTG LWLHNKLGAT DELWAPPSIA SLLTAAVIDN IRLCFHRLSS AVKLKLLLGT 60
LHLPRRTVDE MKAALMDIIQ LATLDSDPWV LMVADILKSF PDTGSLNLDL EEQNPNVQDI 120
LGELREKVSE CEASAMLPLE CQYLNKNALT TLAGPLTPPV KHFQLKRKPK SATLRAELLQ 180
KSTETAQQLK RSAGVPFHAK GRGLLRKMDT TTPLKGIPKQ APFRSPTTPS VFSPSGNRTP 240
IPPSRTPLQK ERGVKLLDIS ELNTVGAGRE AKRRRKTLDT EVVEKPTKEE TVVENATPDY 300
AAGLVSTQKL GSLNSEPTLP STSYLPSTPS VVPASSYIPS SETPPAPPSR EASRPPEEPS 360
APSPTLPTQF KQRAPMYNSG LSPATPAPAA PTSPLTPTTP PAVTPTAQTP PVAMVAPQTQ 420
APAPVQQQPK KNLSLTREQM FAAQEMFKTA NKVTRPEKAL ILGFMAGSRE NPCPEQGDVI 480
QIKLSEHTED LPKADGQGST TMLVDTVFEM NYATGQWTRF KKYKPMTNVS 530 |
Gene Ontology | GO:0032021; C:NELF complex; ISS:UniProtKB. GO:0003682; F:chromatin binding; IDA:MGI. GO:0034244; P:negative regulation of transcription elongation from RNA polymerase II promoter; IMP:MGI. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
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Pfam | |
SMART | |
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PRINTS | |