UniProt Accession

 DHB2_HUMAN; P37059; B2R7T4 

Genbank Protein ID

 L11708; L40802; L40796; L40797; L40798; L40801; AY325910; AK313109; CH471114; BC009581; BC059170 

Genbank Nucleotide ID

 AAA03562.1; AAC41917.1; AAC41917.1; AAC41917.1; AAC41917.1; AAC41917.1; AAP78485.1; BAG35931.1; EAW95519.1; AAH09581.1; AAH59170.1 

Protein Name

 Estradiol 17-beta-dehydrogenase 2 

Protein Synonyms/Alias

 17-beta-hydroxysteroid dehydrogenase type 2; 17-beta-HSD 2; 20 alpha-hydroxysteroid dehydrogenase; 20-alpha-HSD; E2DH; Microsomal 17-beta-hydroxysteroid dehydrogenase; Testosterone 17-beta-dehydrogenase 

Gene Name

 HSD17B2 

Gene Synonyms/Alias

 EDH17B2 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
141	VLQMDITKPVQIKDA	acetylation	[1]

Reference

 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 

Functional Description

 Capable of catalyzing the interconversion of testosterone and androstenedione, as well as estradiol and estrone. Also has 20-alpha-HSD activity. Uses NADH while EDH17B3 uses NADPH. 

Sequence Annotation

 NP_BIND 82 111 NAD (By similarity).
 ACT_SITE 232 232 By similarity.
 BINDING 219 219 Substrate (By similarity).  

Keyword

 Complete proteome; Lipid biosynthesis; Lipid metabolism; Membrane; NAD; Oxidoreductase; Polymorphism; Reference proteome; Signal-anchor; Steroid biosynthesis; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 387 AA 

Protein Sequence

Gene Ontology

 GO:0005789; C:endoplasmic reticulum membrane; TAS:ProtInc.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0047006; F:17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity; TAS:BHF-UCL.
 GO:0004303; F:estradiol 17-beta-dehydrogenase activity; IDA:UniProtKB.
 GO:0050327; F:testosterone 17-beta-dehydrogenase (NAD+) activity; IDA:UniProtKB.
 GO:0047035; F:testosterone dehydrogenase (NAD+) activity; IEA:EC.
 GO:0001701; P:in utero embryonic development; IEA:Compara.
 GO:0001890; P:placenta development; IEA:Compara.
 GO:0032526; P:response to retinoic acid; IDA:BHF-UCL.
 GO:0006694; P:steroid biosynthetic process; IEA:UniProtKB-KW. 

Interpro

 IPR002198; DH_sc/Rdtase_SDR.
 IPR002347; Glc/ribitol_DH.
 IPR016040; NAD(P)-bd_dom.
 IPR020904; Sc_DH/Rdtase_CS. 

Pfam

 PF00106; adh_short 

SMART

  

PROSITE

 PS00061; ADH_SHORT 

PRINTS

 PR00081; GDHRDH.
 PR00080; SDRFAMILY.