UniProt Accession

 GORS1_HUMAN; Q9BQQ3; B3KWC8; Q3SYG7; Q8N272; Q96H42 

Genbank Protein ID

 AJ409349; AK091168; AK124755; CH471055; BC008928; BC075854; BC103826; BC103827 

Genbank Nucleotide ID

 CAC35160.1; BAC03598.1; BAG54090.1; EAW64554.1; AAH08928.1; AAH75854.1; AAI03827.1; AAI03828.1 

Protein Name

 Golgi reassembly-stacking protein 1 

Protein Synonyms/Alias

 Golgi peripheral membrane protein p65; Golgi phosphoprotein 5; GOLPH5; Golgi reassembly-stacking protein of 65 kDa; GRASP65 

Gene Name

 GORASP1 

Gene Synonyms/Alias

 GOLPH5; GRASP65 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
50	IGHSRLNKENDTLKA	ubiquitination	[1]
56	NKENDTLKALLKANV	ubiquitination	[2, 3]
169	KLMVYNSKSDSCREV	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Stacking factor involved in the postmitotic assembly of Golgi stacks from mitotic Golgi fragments. Key structural protein required for the maintenance of the Golgi apparatus integrity: its caspase-mediated cleavage is required for fragmentation of the Golgi during apoptosis. Also mediates, via its interaction with GM130, the docking of transport vesicles with the Golgi membranes. 

Sequence Annotation

 DOMAIN 5 75 PDZ.
 REGION 190 202 Essential for the interaction with GM130
 MOD_RES 216 216 Phosphothreonine.
 LIPID 2 2 N-myristoyl glycine (Probable).  

Keyword

 Alternative splicing; Complete proteome; Golgi apparatus; Lipoprotein; Membrane; Myristate; Phosphoprotein; Polymorphism; Protein transport; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 440 AA 

Protein Sequence

Gene Ontology

 GO:0000139; C:Golgi membrane; TAS:Reactome.
 GO:0000278; P:mitotic cell cycle; TAS:Reactome.
 GO:0050774; P:negative regulation of dendrite morphogenesis; IMP:UniProtKB.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW. 

Interpro

 IPR024958; GRASP55/65_PDZ.
 IPR007583; GRASP55_65.
 IPR001478; PDZ. 

Pfam

 PF04495; GRASP55_65 

SMART

  

PROSITE

 PS50106; PDZ 

PRINTS