| Tag | Content |
|---|
| CPLM ID | CPLM-008840 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Chromaffin granule amine transporter |
Protein Synonyms/Alias | Solute carrier family 18 member 1; Vesicular amine transporter 1; VAT1 |
Gene Name | SLC18A1 |
Gene Synonyms/Alias | VAT1; VMAT1 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 506 | TRMYATQKPTKEFPL | ubiquitination | [1] |
|
Reference | [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW. Nature. 2013 Apr 18;496(7445):372-6. [ PMID: 23503661] |
Functional Description | Involved in the transport of biogenic monoamines, such as serotonin, from the cytoplasm into the secretory vesicles of neuroendocrine and endocrine cells. |
Sequence Annotation | CARBOHYD 58 58 N-linked (GlcNAc...) (Potential).
CARBOHYD 87 87 N-linked (GlcNAc...) (Potential).
CARBOHYD 104 104 N-linked (GlcNAc...) (Potential). |
Keyword | Alternative splicing; Complete proteome; Cytoplasmic vesicle; Endoplasmic reticulum; Glycoprotein; Membrane; Neurotransmitter transport; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 525 AA |
Protein Sequence | MLRTILDAPQ RLLKEGRASR QLVLVVVFVA LLLDNMLFTV VVPIVPTFLY DMEFKEVNSS 60
LHLGHAGSSP HALASPAFST IFSFFNNNTV AVEESVPSGI AWMNDTASTI PPPATEAISA 120
HKNNCLQGTG FLEEEITRVG VLFASKAVMQ LLVNPFVGPL TNRIGYHIPM FAGFVIMFLS 180
TVMFAFSGTY TLLFVARTLQ GIGSSFSSVA GLGMLASVYT DDHERGRAMG TALGGLALGL 240
LVGAPFGSVM YEFVGKSAPF LILAFLALLD GALQLCILQP SKVSPESAKG TPLFMLLKDP 300
YILVAAGSIC FANMGVAILE PTLPIWMMQT MCSPKWQLGL AFLPASVSYL IGTNLFGVLA 360
NKMGRWLCSL IGMLVVGTSL LCVPLAHNIF GLIGPNAGLG LAIGMVDSSM MPIMGHLVDL 420
RHTSVYGSVY AIADVAFCMG FAIGPSTGGA IVKAIGFPWL MVITGVINIV YAPLCYYLRS 480
PPAKEEKLAI LSQDCPMETR MYATQKPTKE FPLGEDSDEE PDHEE 525 |
Gene Ontology | GO:0070083; C:clathrin-sculpted monoamine transport vesicle membrane; TAS:Reactome. GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0015238; F:drug transmembrane transporter activity; IEA:InterPro. GO:0008504; F:monoamine transmembrane transporter activity; TAS:UniProtKB. GO:0006855; P:drug transmembrane transport; IEA:GOC. GO:0006836; P:neurotransmitter transport; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |