| Tag | Content |
|---|
| CPLM ID | CPLM-017495 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | DDB1- and CUL4-associated factor 8 |
Protein Synonyms/Alias | WD repeat-containing protein 42A |
Gene Name | Dcaf8 |
Gene Synonyms/Alias | D1Ucla4; H326; Wdr42a |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 230 | LDFESGHKSNVFQAK | ubiquitination | [1] | | 237 | KSNVFQAKFLPNSGD | ubiquitination | [1] | | 268 | LSATQCCKNTKRVAQ | ubiquitination | [1] | | 315 | RQDRPASKLVVTKEK | ubiquitination | [1] | | 357 | VRIYDQRKIDENENN | ubiquitination | [1] | | 369 | ENNGVLKKFCPHHLV | ubiquitination | [1] | | 432 | HRNNATVKGVNFYGP | ubiquitination | [1] | | 513 | STELTGLKEVIKKNK | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex (By similarity). |
Sequence Annotation | REPEAT 185 224 WD 1.
REPEAT 228 269 WD 2.
REPEAT 275 315 WD 3.
REPEAT 323 363 WD 4.
REPEAT 379 418 WD 5.
REPEAT 426 466 WD 6.
REPEAT 470 509 WD 7.
MOD_RES 100 100 Phosphoserine.
MOD_RES 123 123 Phosphoserine (By similarity).
MOD_RES 124 124 Phosphoserine (By similarity).
MOD_RES 198 198 Omega-N-methylarginine; by PRMT1 (By |
Keyword | Alternative splicing; Complete proteome; Methylation; Phosphoprotein; Reference proteome; Repeat; Ubl conjugation pathway; WD repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 591 AA |
Protein Sequence | MSNKRPNTTD GRTDLANGSL SSSPEEMSGA EEGRETSSGI EVEASDLSLS LTGDDGGPNR 60
TSTESRGTDT ESSGEEKDSD SMEDTGHYSI NDESRGHGHS DEEDEEQPRH RGQRKRASRD 120
QDSSDDERAL EDWVSSETTA LPRPRWQALP ALRERELGSS ARFVYEACGA RVFVQRFRLQ 180
HGLEGHTGCV NTLHFNQRGT WLASGSDDLK VVVWDWVRRQ PVLDFESGHK SNVFQAKFLP 240
NSGDSTLAMC ARDGQVRVAE LSATQCCKNT KRVAQHKGAS HKLALEPDSP CTFLSAGEDA 300
VVFTIDLRQD RPASKLVVTK EKEKKVGLYT IYVNPANTHQ FAVGGRDQYV RIYDQRKIDE 360
NENNGVLKKF CPHHLVNSES KANITCLVYS HDGTELLASY NDEDIYLFNS SHSDGAQYIK 420
RYKGHRNNAT VKGVNFYGPK SEFVVSGSDC GHIFLWEKSS CQIIQFMEGD KGGVVNCLEP 480
HPHLPVLATS GLDHDVKIWA PTAEASTELT GLKEVIKKNK RERDEDSLHH TDLFDSHMLW 540
FLMHHLRQRR HHRRWREPGV GATDADSDES PSSSDTSDEE EGPDRVQCMP S 591 |
Gene Ontology | GO:0080008; C:Cul4-RING ubiquitin ligase complex; ISS:UniProtKB. GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |