UniProt Accession

 PTN7_HUMAN; P35236; B3KXE1; Q53XK4; Q5SXQ0; Q5SXQ1; Q9BV05 

Genbank Protein ID

 D11327; M64322; BT009848; AK127214; AL592300; BC001746 

Genbank Nucleotide ID

 BAA01946.1; AAA59531.1; AAP88850.1; BAG54453.1; CAI13108.1; AAH01746.2 

Protein Name

 Tyrosine-protein phosphatase non-receptor type 7 

Protein Synonyms/Alias

 Hematopoietic protein-tyrosine phosphatase; HEPTP; Protein-tyrosine phosphatase LC-PTP 

Gene Name

 PTPN7 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
73	PEKTPAKKHVRLQER	ubiquitination	[1]
142	QLEEEFLKIPSNFVS	ubiquitination	[1]
161	DIPGHASKDRYKTIL	ubiquitination	[1]
165	HASKDRYKTILPNPQ	ubiquitination	[1]
242	QLREGKEKCVHYWPT	ubiquitination	[1]
265	QIRIQDMKECPEYTV	ubiquitination	[1]
287	QEERRSVKHILFSAW	ubiquitination	[1]
351	RIGCQQLKARGEVDI	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Protein phosphatase that acts preferentially on tyrosine-phosphorylated MAPK1. Plays a role in the regulation of T and B-lymphocyte development and signal transduction. 

Sequence Annotation

 DOMAIN 97 350 Tyrosine-protein phosphatase.
 REGION 38 51 Interaction with MAP kinases.
 REGION 291 297 Substrate binding.
 ACT_SITE 291 291 Phosphocysteine intermediate.
 BINDING 257 257 Substrate.
 BINDING 335 335 Substrate.
 MOD_RES 44 44 Phosphoserine.
 MOD_RES 66 66 Phosphothreonine.
 MOD_RES 93 93 Phosphoserine.
 MOD_RES 143 143 Phosphoserine.
 MOD_RES 291 291 Cysteine sulfenic acid (-SOH) (By  

Keyword

 3D-structure; Alternative splicing; Complete proteome; Cytoplasm; Cytoskeleton; Hydrolase; Oxidation; Phosphoprotein; Protein phosphatase; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 360 AA 

Protein Sequence

Gene Ontology

 GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
 GO:0005829; C:cytosol; IDA:BHF-UCL.
 GO:0009898; C:internal side of plasma membrane; IDA:UniProtKB.
 GO:0004725; F:protein tyrosine phosphatase activity; TAS:ProtInc. 

Interpro

 IPR000387; Tyr/Dual-sp_Pase.
 IPR016130; Tyr_Pase_AS.
 IPR008356; Tyr_Pase_KIM-con.
 IPR000242; Tyr_Pase_rcpt/non-rcpt. 

Pfam

 PF00102; Y_phosphatase 

SMART

 SM00194; PTPc 

PROSITE

 PS00383; TYR_PHOSPHATASE_1
 PS50056; TYR_PHOSPHATASE_2
 PS50055; TYR_PHOSPHATASE_PTP 

PRINTS

 PR01778; KIMPTPASE.
 PR00700; PRTYPHPHTASE.