CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-008779
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Signal transduction protein MDG1 
Protein Synonyms/Alias
 Multicopy suppressor of defective G-protein 1 
Gene Name
 MDG1 
Gene Synonyms/Alias
 YNL173C; N1673 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
124LIEPEAEKRAKKLRKubiquitination[1]
169DETQQVNKTGKNADGubiquitination[1]
172QQVNKTGKNADGLSGubiquitination[1]
210HPKVNLVKSEGYVTDubiquitination[1]
221YVTDGLGKTQSSESRubiquitination[1]
283KFEKPEEKVPVSSITubiquitination[1]
303TSVKPTGKVATETQTubiquitination[1, 2]
314ETQTYETKQGAPTAAubiquitination[1, 2]
Reference
 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301]
 [2] Sites of ubiquitin attachment in Saccharomyces cerevisiae.
 Starita LM, Lo RS, Eng JK, von Haller PD, Fields S.
 Proteomics. 2012 Jan;12(2):236-40. [PMID: 22106047] 
Functional Description
 Involved in G-protein mediated signal transduction and in the regulation of polarized cell growth in pheromone-induced cells. 
Sequence Annotation
 MOD_RES 160 160 Phosphoserine.
 MOD_RES 216 216 Phosphothreonine.
 MOD_RES 288 288 Phosphoserine.  
Keyword
 Cell membrane; Complete proteome; Membrane; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 366 AA 
Protein Sequence
MQSSLPQFTF KWPKGPEAII LTGTFDDWKG TLPMVKDPSG AFEITLPVTF DSPSSKFYFK 60
FIVDGQWLPS KDYKVNIDEG VENNFITEED VIKQRENGSS TLVPESAGLA VSKNAPLIEP 120
EAEKRAKKLR KFKIKRVIKT NKQTGERSIF SQEVVELPDS EDETQQVNKT GKNADGLSGT 180
TTIIENNVGV NEEKAIKPYE ENHPKVNLVK SEGYVTDGLG KTQSSESRLY ELSAEDLEKE 240
EEEEDEDKGG GKDTSTSADA EASEDQNKEP LSKSAKFEKP EEKVPVSSIT SHAKETSVKP 300
TGKVATETQT YETKQGAPTA AAKKIEAKKA TRPSKPKGTK ETPNKGVQKN PAKNGGFFKK 360
LAQLLK 366 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:SGD.
 GO:0005634; C:nucleus; IDA:SGD.
 GO:0005886; C:plasma membrane; IDA:SGD.
 GO:0000750; P:pheromone-dependent signal transduction involved in conjugation with cellular fusion; IMP:SGD. 
Interpro
  
Pfam
  
SMART
  
PROSITE
  
PRINTS