CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-024607
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 BAG family molecular chaperone regulator 1 
Protein Synonyms/Alias
 BAG-1; Bcl-2-associated athanogene 1 
Gene Name
 Bag1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
255DLEVSVEKTANHLEEacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Inhibits the pro-apoptotic function of PPP1R15A, and has anti-apoptotic activity. Markedly increases the anti-cell death function of BCL2 induced by various stimuli (By similarity). 
Sequence Annotation
 REPEAT 102 111 1.
 REPEAT 114 119 2.
 REPEAT 120 125 3.
 REPEAT 126 131 4.
 REPEAT 132 137 5.
 REPEAT 144 149 6.
 REPEAT 150 155 7.
 DOMAIN 157 237 Ubiquitin-like.
 DOMAIN 259 339 BAG.
 REGION 114 212 7 X 6 AA tandem repeat of E-E-X(4).
 REGION 185 232 Interaction with HSPA8 (By similarity).
 REGION 229 358 Interaction with PPP1R15A (By  
Keyword
 Apoptosis; Chaperone; Complete proteome; Cytoplasm; Nucleus; Reference proteome; Repeat; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 358 AA 
Protein Sequence
MADRGGARRP RGDQEPLGPR LRAPRSARET RQSESRAERG LPPSQRSSVR SAASGHDRST 60
RGAASGACKP RVKKKVRPRS SQSEKVAHSK ELTRSKKLTR SKKVTGTQEA TQVEEVTTIE 120
EATQTEEITV AEEVTQTENM AQTEEMVQTE EMEPPTLSVV VTHSNERYDL LVTPQQGNSE 180
PIVQDLAQLV EEATGVPLPF QKLIFKGKSL KEMETPLSAL GMQNGCRVML IGEKSNPEEE 240
AELKKLKDLE VSVEKTANHL EELNKELSDI QQGFLAKELQ AEALCRLDRK IKATIEQFMK 300
ILEEIDTMVL PENFKDSRLK RKNLVKKVQV FLAECDTVEQ YICQETERLQ STNLALPE 358 
Gene Ontology
 GO:0005829; C:cytosol; IDA:RGD.
 GO:0005739; C:mitochondrion; IDA:RGD.
 GO:0005634; C:nucleus; IDA:RGD.
 GO:0048471; C:perinuclear region of cytoplasm; IDA:RGD.
 GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
 GO:0043066; P:negative regulation of apoptotic process; IMP:RGD.
 GO:0042493; P:response to drug; IEP:RGD.
 GO:0010226; P:response to lithium ion; IEP:RGD.
 GO:0035094; P:response to nicotine; IEP:RGD. 
Interpro
 IPR003103; BAG_domain.
 IPR017093; Molecular_chp_reg_BAG_1.
 IPR000626; Ubiquitin.
 IPR019955; Ubiquitin_supergroup. 
Pfam
 PF02179; BAG
 PF00240; ubiquitin 
SMART
 SM00264; BAG
 SM00213; UBQ 
PROSITE
 PS51035; BAG
 PS00299; UBIQUITIN_1
 PS50053; UBIQUITIN_2 
PRINTS