CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-002511
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Beta-2 adrenergic receptor 
Protein Synonyms/Alias
 Beta-2 adrenoreceptor; Beta-2 adrenoceptor 
Gene Name
 ADRB2 
Gene Synonyms/Alias
 ADRB2R; B2AR 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
263HGLRRSSKFCLKEHKubiquitination[1]
270KFCLKEHKALKTLGIubiquitination[1]
348CLRRSSLKAYGNGYSubiquitination[1]
372GYHVEQEKENKLLCEubiquitination[1]
375VEQEKENKLLCEDLPubiquitination[1]
Reference
 [1] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
 Beta-adrenergic receptors mediate the catecholamine- induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine. 
Sequence Annotation
 REGION 193 207 Agonist and antagonist binding.
 REGION 286 293 Agonist and antagonist binding.
 REGION 312 316 Agonist and antagonist binding.
 MOTIF 410 413 PDZ-binding.
 BINDING 113 113 Agonist or antagonist.
 BINDING 118 118 Agonist or antagonist.
 MOD_RES 141 141 Phosphotyrosine.
 MOD_RES 246 246 Phosphoserine.
 MOD_RES 261 261 Phosphoserine; by PKA (Potential).
 MOD_RES 262 262 Phosphoserine; by PKA (Potential).
 MOD_RES 345 345 Phosphoserine; by PKA.
 MOD_RES 346 346 Phosphoserine; by PKA.
 MOD_RES 355 355 Phosphoserine; by BARK (Probable).
 MOD_RES 356 356 Phosphoserine; by BARK (Probable).
 MOD_RES 382 382 4-hydroxyproline.
 MOD_RES 395 395 4-hydroxyproline.
 LIPID 341 341 S-palmitoyl cysteine.
 CARBOHYD 6 6 N-linked (GlcNAc...) (Probable).
 CARBOHYD 15 15 N-linked (GlcNAc...) (Probable).
 DISULFID 106 191
 DISULFID 184 190  
Keyword
 3D-structure; Cell membrane; Complete proteome; Disulfide bond; G-protein coupled receptor; Glycoprotein; Hydroxylation; Lipoprotein; Membrane; Palmitate; Phosphoprotein; Polymorphism; Receptor; Reference proteome; Transducer; Transmembrane; Transmembrane helix; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 413 AA 
Protein Sequence
MGQPGNGSAF LLAPNGSHAP DHDVTQERDE VWVVGMGIVM SLIVLAIVFG NVLVITAIAK 60
FERLQTVTNY FITSLACADL VMGLAVVPFG AAHILMKMWT FGNFWCEFWT SIDVLCVTAS 120
IETLCVIAVD RYFAITSPFK YQSLLTKNKA RVIILMVWIV SGLTSFLPIQ MHWYRATHQE 180
AINCYANETC CDFFTNQAYA IASSIVSFYV PLVIMVFVYS RVFQEAKRQL QKIDKSEGRF 240
HVQNLSQVEQ DGRTGHGLRR SSKFCLKEHK ALKTLGIIMG TFTLCWLPFF IVNIVHVIQD 300
NLIRKEVYIL LNWIGYVNSG FNPLIYCRSP DFRIAFQELL CLRRSSLKAY GNGYSSNGNT 360
GEQSGYHVEQ EKENKLLCED LPGTEDFVGH QGTVPSDNID SQGRNCSTND SLL 413 
Gene Ontology
 GO:0016324; C:apical plasma membrane; IEA:Compara.
 GO:0005768; C:endosome; TAS:ProtInc.
 GO:0005887; C:integral to plasma membrane; IDA:BHF-UCL.
 GO:0005764; C:lysosome; TAS:ProtInc.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0043235; C:receptor complex; IDA:HGNC.
 GO:0004941; F:beta2-adrenergic receptor activity; IDA:HGNC.
 GO:0051380; F:norepinephrine binding; IDA:HGNC.
 GO:0015459; F:potassium channel regulator activity; IDA:BHF-UCL.
 GO:0042803; F:protein homodimerization activity; IDA:HGNC.
 GO:0007190; P:activation of adenylate cyclase activity; IDA:HGNC.
 GO:0007171; P:activation of transmembrane receptor protein tyrosine kinase activity; TAS:ProtInc.
 GO:0007189; P:adenylate cyclase-activating G-protein coupled receptor signaling pathway; IEA:Compara.
 GO:0007188; P:adenylate cyclase-modulating G-protein coupled receptor signaling pathway; TAS:ProtInc.
 GO:0045453; P:bone resorption; IEA:Compara.
 GO:0050873; P:brown fat cell differentiation; IEA:Compara.
 GO:0002032; P:desensitization of G-protein coupled receptor protein signaling pathway by arrestin; IDA:HGNC.
 GO:0002024; P:diet induced thermogenesis; IEA:Compara.
 GO:0008333; P:endosome to lysosome transport; TAS:ProtInc.
 GO:0031649; P:heat generation; IEA:Compara.
 GO:0040015; P:negative regulation of multicellular organism growth; IEA:Compara.
 GO:0045986; P:negative regulation of smooth muscle contraction; IEA:Compara.
 GO:0030501; P:positive regulation of bone mineralization; IEA:Compara.
 GO:0043410; P:positive regulation of MAPK cascade; IDA:HGNC.
 GO:0031398; P:positive regulation of protein ubiquitination; IMP:BHF-UCL.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0006898; P:receptor-mediated endocytosis; IDA:HGNC.
 GO:0002028; P:regulation of sodium ion transport; IEA:Compara.
 GO:0009409; P:response to cold; IEA:Compara.
 GO:0002025; P:vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure; IEA:Compara. 
Interpro
 IPR000332; Adrgc_rcpt_B2.
 IPR002233; Adrnrgc_rcpt.
 IPR000276; GPCR_Rhodpsn.
 IPR017452; GPCR_Rhodpsn_7TM. 
Pfam
 PF00001; 7tm_1 
SMART
  
PROSITE
 PS00237; G_PROTEIN_RECEP_F1_1
 PS50262; G_PROTEIN_RECEP_F1_2 
PRINTS
 PR01103; ADRENERGICR.
 PR00562; ADRENRGCB2AR.
 PR00237; GPCRRHODOPSN.