| Tag | Content |
|---|
| CPLM ID | CPLM-008439 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Adenylate cyclase type 9 |
Protein Synonyms/Alias | ATP pyrophosphate-lyase 9; Adenylate cyclase type IX; Adenylyl cyclase 9; Adenylyl cyclase type 10; ACTP10 |
Gene Name | Adcy9 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 78 | GRLRRQKKLPQLFER | ubiquitination | [1] | | 327 | GKDLEVEKALKERMI | ubiquitination | [1] | | 564 | SVVADQLKGLKTYLI | ubiquitination | [1] | | 567 | ADQLKGLKTYLISGQ | ubiquitination | [1] | | 699 | LCEILQEKGRWAGVS | ubiquitination | [1] | | 723 | RFKNIREKTDAHFVD | ubiquitination | [1] | | 773 | SYQEEVIKNSPVKTF | ubiquitination | [1] | | 1218 | ESYRVLSKMGYDFDY | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | May play a fundamental role in situations where fine interplay between intracellular calcium and cAMP determines the cellular function. May be a physiologically relevant docking site for calcineurin. |
Sequence Annotation | METAL 399 399 Magnesium 1 (By similarity).
METAL 399 399 Magnesium 2 (By similarity).
METAL 400 400 Magnesium 2; via carbonyl oxygen (By
METAL 443 443 Magnesium 1 (By similarity).
METAL 443 443 Magnesium 2 (By similarity).
MOD_RES 608 608 Phosphothreonine.
MOD_RES 610 610 Phosphoserine.
MOD_RES 613 613 Phosphoserine.
MOD_RES 1259 1259 Phosphoserine (By similarity).
MOD_RES 1307 1307 Phosphoserine (By similarity).
CARBOHYD 206 206 N-linked (GlcNAc...) (Potential).
CARBOHYD 955 955 N-linked (GlcNAc...) (Potential).
CARBOHYD 964 964 N-linked (GlcNAc...) (Potential). |
Keyword | ATP-binding; cAMP biosynthesis; Complete proteome; Glycoprotein; Lyase; Magnesium; Membrane; Metal-binding; Nucleotide-binding; Phosphoprotein; Reference proteome; Repeat; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1353 AA |
Protein Sequence | MASSPHQQLL HHHSTEVSCD SSGDSNSVRV KINPKQLSSN THPKHCKYSI SSSCSSSGDS 60
GGLPRRVGGG GRLRRQKKLP QLFERASSRW WDPKFDSMNL EEACLERCFP QTQRRFRYAL 120
FYVGFACLLW SIYFAVHMKS KVIVMVVPAL CFLVVCVGFF LFTFTKLYAR HYAWTSLALT 180
LLVFALTLAA QFQVWTPLSG RVDSSNHTLT ATPADTCLSQ VGSFSICIEV LLLLYTVMQL 240
PLYLSLFLGV VYSVLFETFG YHFRNEDCYP SPGPGALHWE LLSRALLHVC IHAIGIHLFV 300
MSQVRSRSTF LKVGQSIMHG KDLEVEKALK ERMIHSVMPR IIADDLMKQG DEESENSVKR 360
HATSSPKNRK KKSSIQKAPI AFRPFKMQQI EEVSILFADI VGFTKMSANK SAHALVGLLN 420
DLFGRFDRLC EQTKCEKIST LGDCYYCVAG CPEPRADHAY CCIEMGLGMI KAIEQFCQEK 480
KEMVNMRVGV HTGTVLCGIL GMRRFKFDVW SNDVNLANLM EQLGVAGKVH ISEATAKYLD 540
DRYEMEDGRV IERLGQSVVA DQLKGLKTYL ISGQRAKESH CSCAEALLSG FEVIDDSRES 600
SGPRGQGTAS PGSVSDLAQT VKTFDNLKTC PSCGITFAPK SEAGAEGGTV QNGCQDEPKT 660
STKASGGPNS KTQNGLLSPP AEEKLTNSQT SLCEILQEKG RWAGVSLDQS ALLPLRFKNI 720
REKTDAHFVD VIKEDSLMKD YFFKPPINQF SLNFLDQELE RSYRTSYQEE VIKNSPVKTF 780
ASATFSSLLD VFLSTTVFLI LSITCFLKYG ATATPPPPAA LAVFGADLLL EVLSLIVSIR 840
MVFFLEDVMT CTKWLLEWIA GWLPRHCIGA ILVSLPALAV YSHITSEFET NIHVTMFTGS 900
AVLVAVVHYC NFCQLSSWMR SSLATIVGAG LLLLLHISLC QDSSIVMSPL DSAQNFSAQR 960
NPCNSSVLQD GRRPASLIGK ELILTFFLLL LLVWFLNREF EVSYRLHYHG DVEADLHRTK 1020
IQSMRDQADW LLRNIIPYHV AEQLKVSQTY SKNHDSGGVI FASIVNFSEF YEENYEGGKE 1080
CYRVLNELIG DFDELLSKPD YNSIEKIKTI GATYMAASGL NTAQCQEGGH PQEHLRILFE 1140
FAKEMMRVVD DFNNNMLWFN FKLRVGFNHG PLTAGVIGTT KLLYDIWGDT VNIASRMDTT 1200
GVECRIQVSE ESYRVLSKMG YDFDYRGTVN VKGKGQMKTY LYPKCTDNGV VPQHQLSISP 1260
DIRVQVDGSI GRSPTDEIAN LVPSVQYSDK ASLGSDDSTQ AKEARLSSKR SWREPVKAEE 1320
RFPFGKAIEK DSCEDIGVEE ASELSKLNVS KSV 1353 |
Gene Ontology | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0005886; C:plasma membrane; TAS:MGI. GO:0004016; F:adenylate cyclase activity; TAS:MGI. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0007190; P:activation of adenylate cyclase activity; TAS:MGI. GO:0035556; P:intracellular signal transduction; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |