CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-044939
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Eukaryotic translation initiation factor 3 subunit G 
Protein Synonyms/Alias
  
Gene Name
 EIF3G 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
65EVINGNIKTVTEYKIubiquitination[1]
71IKTVTEYKIDEDGKKubiquitination[2, 3]
78KIDEDGKKFKVRIVRubiquitination[2]
150EEEDPMNKLKGQKIVubiquitination[2, 3]
152EDPMNKLKGQKIVSCubiquitination[2]
163IVSCRICKGDHWTTRubiquitination[2, 3]
182DTLGPMQKELAEQLGubiquitination[1, 4]
195LGLSTGEKEKLPGELubiquitination[2]
197LSTGEKEKLPGELEPubiquitination[3, 4]
211PVQATQNKTGKYVPPubiquitination[1, 3, 4]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [4] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983
Functional Description
 Component of the eukaryotic translation initiation factor 3 (eIF-3) complex (By similarity). 
Sequence Annotation
  
Keyword
 Complete proteome; Cytoplasm; Initiation factor; Protein biosynthesis; Reference proteome; RNA-binding. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 263 AA 
Protein Sequence
MPTGDFDSKP SWADQVEEEG EDDKCVTSEL LKGIPLATGD TSPEPELLPG APLPPPKEVI 60
NGNIKTVTEY KIDEDGKKFK VRIVRTFRIE TRKASKAVAR RKNWKKFGNS EFDPPGPNVA 120
TTTVSDDVSM TFITSKEDLN CQEEEDPMNK LKGQKIVSCR ICKGDHWTTR CPYKDTLGPM 180
QKELAEQLGL STGEKEKLPG ELEPVQATQN KTGKYVPPSL RDGASRRGES MQPNRRADDN 240
ATIRVTNLSE DTRETDLQEL FRP 263 
Gene Ontology
 GO:0005852; C:eukaryotic translation initiation factor 3 complex; IEA:InterPro.
 GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW. 
Interpro
 IPR017334; eIF3_g.
 IPR024675; eIF3g_N. 
Pfam
 PF12353; eIF3g 
SMART
  
PROSITE
  
PRINTS